1. Academic Validation
  2. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase

Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase

  • Science. 2004 Nov 19;306(5700):1383-6. doi: 10.1126/science.1100747.
Robert Zimmermann 1 Juliane G Strauss Guenter Haemmerle Gabriele Schoiswohl Ruth Birner-Gruenberger Monika Riederer Achim Lass Georg Neuberger Frank Eisenhaber Albin Hermetter Rudolf Zechner
Affiliations

Affiliation

  • 1 Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Abstract

Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic Enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and Insulin resistance. Until now, hormone-sensitive Lipase (HSL) was the only Enzyme known to hydrolyze triglycerides in mammalian adipose tissue. Here, we report that a second Enzyme, adipose triglyceride Lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. It is interesting that ATGL contains a "patatin domain" common to plant acyl-hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.

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