SPOCK1 - SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 Gene

Homo sapiens

Also known as TIC1; SPOCK; TESTICAN

Gene ID: 6695 | Gene type: protein coding

About SPOCK1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:136,975,298-137,499,326 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 3 paralogues. Biased expression in brain (RPKM 74.1), prostate (RPKM 36.6) and 10 other tissues.

Summary

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]

SPOCK1 Products(1)

mRNA	Protein	Name
NM_004598.4	NP_004589.1	testican-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	9323035	GOA
enables cysteine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	14511383	GOA
enables metalloendopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	11751414	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell-substrate adhesion	IDA IDA: Inferred from direct assay	12853036	GOA
involved in negative regulation of endopeptidase activity	IDA IDA: Inferred from direct assay	14511383	GOA
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	12853036	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	14511383	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPOCK1 Protein Structure

Kazal_2

SPARC_Ca_bdg

Thyroglobulin_1

0
100
200
300
400
439 a.a.

Protein Preferred Names

Protein Names

testican-1

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1

SPOCK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPOCK1	Q08629	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SPOCK1	Q08629	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	SPOCK1	Q08629	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	SPOCK1	Q08629	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
Intra	SPOCK1	Q08629	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
Intra	SPOCK1	Q08629	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPOCK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76654	Testican 1/SPOCK1 Protein, Human (sf9, His)	Q08629 (M1-W439)	≥95%

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 101

DFNB101	Autosomal Recessive Nonsyndromic Deafness 101
Autosomal Recessive Deafness 101	Deafness, Autosomal Recessive, 101
Deafness, Autosomal Recessive, Type 101

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13695	SPOCK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPOCK1	MGD	MGI:105371
Canis familiaris	SPOCK1	VGNC	VGNC:59043
Rattus norvegicus	SPOCK1	RGD	RGD:1311496
Felis catus	SPOCK1	VGNC	VGNC:102331
Macaca mulatta	SPOCK1	VGNC	VGNC:84514
Others	SPOCK1	NCBI

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