1. Gene
  2. BCL2L13 - BCL2 like 13 Gene

BCL2L13 - BCL2 like 13 Gene

Homo sapiens

Also known as MIL1; BCL-RAMBO; Bcl2-L-13

Gene ID: 23786 | Gene type: protein coding

About BCL2L13

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:17,628,877-17,730,855 (from NCBI)

This gene has 17 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in fat (RPKM 9.5), adrenal (RPKM 9.0) and 25 other tissues.

Summary

This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in Apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

BCL2L13 Products(12)

mRNA Protein Name
NM_001270726.1 NP_001257655.1 bcl-2-like protein 13 isoform b
NM_001270727.1 NP_001257656.1 bcl-2-like protein 13 isoform c
NM_001270728.2 NP_001257657.1 bcl-2-like protein 13 isoform d
NM_001270729.2 NP_001257658.1 bcl-2-like protein 13 isoform e
NM_001270730.2 NP_001257659.1 bcl-2-like protein 13 isoform e
NM_001270731.2 NP_001257660.1 bcl-2-like protein 13 isoform e
NM_001270732.2 NP_001257661.1 bcl-2-like protein 13 isoform f
NM_001270733.2 NP_001257662.1 bcl-2-like protein 13 isoform g
NM_001270734.2 NP_001257663.1 bcl-2-like protein 13 isoform h
NM_001270735.2 NP_001257664.1 bcl-2-like protein 13 isoform i
NM_001363824.1 NP_001350753.1 bcl-2-like protein 13 isoform j
NM_015367.4 NP_056182.2 bcl-2-like protein 13 isoform a
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
11262395 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL2L13 Protein Structure

Bcl-2

Bcl-2: Apoptosis regulator proteins, Bcl-2 family (104 - 200)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 13

BCL2-like 13 (apoptosis facilitator)

BCL2L13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra BCL2L13 Q9BXK5 VAMP4 Homo sapiens O75379-2
Validated Y2H
25416956
Intra BCL2L13 Q9BXK5 VAMP4 Homo sapiens O75379-2
Y2H Array
25416956
Intra BCL2L13 Q9BXK5 VAMP4 Homo sapiens O75379-2
Y2H Prey Pooling
25416956
Intra BCL2L13 Q9BXK5 BET1 Homo sapiens Q53XK0
Y2H Prey Pooling
25416956
Intra BCL2L13 Q9BXK5 TMEM128 Homo sapiens Q5BJH2
Y2H Prey Pooling
25416956
Intra BCL2L13 Q9BXK5 TMEM128 Homo sapiens Q5BJH2
Validated Y2H
25416956
Intra BCL2L13 Q9BXK5 TMEM128 Homo sapiens Q5BJH2
Y2H Array
25416956
Intra BCL2L13 Q9BXK5 DEFB127 Homo sapiens Q9H1M4
Validated Y2H
32296183
Intra BCL2L13 Q9BXK5 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra BCL2L13 Q9BXK5 TMEM242 Homo sapiens Q9NWH2
Y2H Prey Pooling
32296183
Intra BCL2L13 Q9BXK5 TMEM242 Homo sapiens Q9NWH2
Y2H Array
32296183
Intra BCL2L13 Q9BXK5 NINJ2 Homo sapiens Q9NZG7
Y2H Array
25416956
Intra BCL2L13 Q9BXK5 NINJ2 Homo sapiens Q9NZG7
Y2H Prey Pooling
25416956
Intra BCL2L13 Q9BXK5 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra BCL2L13 Q9BXK5 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra BCL2L13 Q9BXK5 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra BCL2L13 Q9BXK5 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra BCL2L13 Q9BXK5 TNMD Homo sapiens Q9H2S6-2
Validated Y2H
32296183
Intra BCL2L13 Q9BXK5 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra BCL2L13 Q9BXK5 TM6SF2 Homo sapiens Q9BZW4
Validated Y2H
32296183
Intra BCL2L13 Q9BXK5 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra BCL2L13 Q9BXK5 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra BCL2L13 Q9BXK5 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra BCL2L13 Q9BXK5 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra BCL2L13 Q9BXK5 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
Intra BCL2L13 Q9BXK5 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra BCL2L13 Q9BXK5 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra BCL2L13 Q9BXK5 TMUB2 Homo sapiens Q71RG4
Validated Y2H
25416956
Intra BCL2L13 Q9BXK5 TMUB2 Homo sapiens Q71RG4
Y2H Array
25416956
Intra BCL2L13 Q9BXK5 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra BCL2L13 Q9BXK5 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra BCL2L13 Q9BXK5 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra BCL2L13 Q9BXK5 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra BCL2L13 Q9BXK5 VAMP3 Homo sapiens Q15836
Y2H Prey Pooling
25416956
Intra BCL2L13 Q9BXK5 VAMP3 Homo sapiens Q15836
Validated Y2H
25416956
Intra BCL2L13 Q9BXK5 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Intra BCL2L13 Q9BXK5 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra BCL2L13 Q9BXK5 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra BCL2L13 Q9BXK5 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra BCL2L13 Q9BXK5 SOD1 Homo sapiens P00441
Anti Tag CoIP
28514442
Intra BCL2L13 Q9BXK5 SOD1 Homo sapiens P00441
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Canis familiaris BCL2L13 VGNC VGNC:38409
Macaca mulatta BCL2L13 VGNC VGNC:84544
Felis catus BCL2L13 VGNC VGNC:60084
Rattus norvegicus BCL2L13 RGD RGD:1306985
Mus musculus BCL2L13 MGD MGI:2136959
Bos taurus BCL2L13 VGNC VGNC:56193