BPI - bactericidal permeability increasing protein Gene

Homo sapiens

Also known as rBPI; BPIFD1

Gene ID: 671 | Gene type: protein coding

About BPI

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,304,156-38,337,505 (from NCBI)

This gene has 6 transcripts (splice variants), 123 orthologues and 12 paralogues. Restricted expression toward bone marrow (RPKM 549.1).

Summary

This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]

BPI Products(1)

mRNA	Protein	Name
NM_001725.3	NP_001716.3	bactericidal permeability-increasing protein precursor

BPI Protein Structure

LBP_BPI_CETP

LBP_BPI_CETP_C

0
100
200
300
400
487 a.a.

Protein Preferred Names

Protein Names

bactericidal permeability-increasing protein

BPI fold containing family D, member 1

Recombinant BPI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7644	BPI Protein, Human (HEK293, His)	AAH40955.1 (V32-K487)	≥95%

Related Diseases

Diseases

Alias

Meningococcemia

Reactive Arthritis

Postdysenteric Arthropathy	Reiter Disease
Pira	Reiter Syndrome
Reiters Syndrome	Arthritis, Reactive
Fiessinger Leroy Reiter Syndrome	Post-Bacterial Arthropathy
Reiter'S Disease	Post-Infectious Arthritis
Post-Infectious Reactive Arthropathy	Reiter'S Syndrome
Arthritis Urethritica	Fiessinger-Leroy Disease
Polyarthritis Enterica	Venereal Arthritis
Arthritis Reactive	Post-Dysenteric Arthropathy
Arthritis, Venereal

Vasculitis

Angiitis	Autoimmune Vasculitis
Systemic Vasculitis	Vasculitis, Autoimmune

Bronchiectasis

Polynesian Bronchiectasis	Kartagener Syndrome
Bronchiectasis Nos

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Dacryocystitis

Nasolacrimal Sac Infection

Acute Inflammation Of Lacrimal Passage

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Toxic Shock Syndrome

Septic Shock	Toxic Shock
Tss	Shock, Septic
Staphylococcal Toxic Shock Syndrome	Tss - [Toxic Shock Syndrome]

Alpha-1-Antitrypsin Deficiency

Alpha 1-Antitrypsin Deficiency	Alpha-1 Antitrypsin Deficiency
Aat Deficiency	Aatd
A1ATD	Emphysema Due To Aat Deficiency
A1at Deficiency	Emphysema-Cirrhosis, Due To Aat Deficiency
Hemorrhagic Diathesis Due To Antithrombin Pittsburgh	Alpha-1 Antiprotease Deficiency
Alpha 1 Antitrypsin Deficiency	Aat
Alpha-1 Protease Inhibitor Deficiency	Alpha-1 Related Emphysema
Genetic Emphysema	Hereditary Pulmonary Emphysema
Inherited Emphysema	Alpha-1-Proteinase Inhibitor Deficiency
Alpha1-Antitrypsin Deficiency	Alpha-1-Antitrypsin Deficiency, Autosomal Recessive
Emphysema, Hereditary Pulmonary	Aatd - [Alpha-1-Antitrypsin] Deficiency

Mastitis

Breast Inflammation	Inflammatory Breast Disease
Inflammatory Disease Of Breast	Inflammation Of Non-Human Mammary Gland
Inflammatory Disorder Of Breast	Mastitis Nos
Acute Mastitis Nos	Acute Nonpuerperal Mastitis
Nonpuerperal Mastitis Nos	Subacute Mastitis Nos

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Bacteremia 2

Bacteremia	Bacteremia, Susceptibility To, 2
BACTS2	Bacteremia, Susceptibility To
Bacteremia, Susceptibility To, Type 2

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15164A	Icotinib	Inhibitor	99.99%	Yes
HY-15164	Icotinib Hydrochloride	Inhibitor	99.81%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-114356	BPI-9016M	Inhibitor	97.12%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109189	Rezivertinib	Inhibitor	99.43%	Unkown
HY-141703A	DC-BPi-11 hydrochloride	Inhibitor	≥97.0%	Unkown
HY-150211	DC-BPi-03	Inhibitor	99.77%	Unkown
HY-141703	DC-BPi-11	Inhibitor	/	Unkown
HY-15164AS	Icotinib-d4		/	Unkown
HY-RS01580	BPI Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-164464	BPI-15086	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BPI	RGD	RGD:1303179
Mus musculus	BPI	MGD	MGI:3045315
Canis familiaris	BPI	VGNC	VGNC:49649
Felis catus	BPI	VGNC	VGNC:60152
Bos taurus	BPI	VGNC	VGNC:97246
Macaca mulatta	BPI	VGNC	VGNC:70277
Others	BPI	NCBI

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