2. Gene
  3. Jam2 - junction adhesion molecule 2 Gene

Jam2 - junction adhesion molecule 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as JAM-2; JAM-B; Jcam2; VE-JAM; 1110002N23Rik; 2410030G21Rik; 2410167M24Rik

Gene ID: 67374 | Gene type: protein coding

About Jam2

Summary

Predicted to enable Integrin binding activity. Involved in several processes, including hematopoietic stem cell migration to bone marrow; leukocyte tethering or rolling; and negative regulation of myelination. Acts upstream of or within negative regulation of cell adhesion. Located in cell surface; somatodendritic compartment; and tight junction. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]

Jam2 Products(1)

mRNA Protein Name
NM_023844.5 NP_076333.3 junctional adhesion molecule B precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16093349 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
24357068 MGI
involved in cellular extravasation IDA
IDA: Inferred from direct assay
12239159 MGI
involved in hematopoietic stem cell migration to bone marrow IMP
IMP: Inferred from mutant phenotype
24357068 MGI
involved in leukocyte tethering or rolling IDA
IDA: Inferred from direct assay
19740376 MGI
acts upstream of or within negative regulation of cell adhesion IGI
IGI: Inferred from genetic interaction
16093349 MGI
involved in negative regulation of myelination IMP
IMP: Inferred from mutant phenotype
27499083 MGI
involved in positive regulation of lymphocyte migration IMP
IMP: Inferred from mutant phenotype
12239159 MGI
involved in spermatid development IDA
IDA: Inferred from direct assay
15372036 MGI
Cellular Component GO Annotation Evidence Reference Source
NOT located in axon IDA
IDA: Inferred from direct assay
27499083 MGI
located in cell surface IDA
IDA: Inferred from direct assay
12239159 MGI
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
27499083 MGI
located in tight junction IDA
IDA: Inferred from direct assay
15372036 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

junctional adhesion molecule B

junction adhesion molecule B

junction cell adhesion molecule 2

junctional adhesion molecule 2

vascular endothelial junction-associated molecule

Recombinant Jam2 Proteins

Cat. No. Product Name Accession Purity
HY-P73259 JAM-B/CD322 Protein, Mouse (HEK293, Fc) Q9JI59 (F29-N236) ≥95%
HY-P73260 JAM-B/CD322 Protein, Mouse (HEK293, His) Q9JI59 (F29-N236) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07027 JAM2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jam2 NCBI NCBI:58494
Rattus norvegicus Jam2 NCBI NCBI:619374