1. Gene
  2. SSX5 - SSX family member 5 Gene

SSX5 - SSX family member 5 Gene

Homo sapiens
Gene ID: 6758 | Gene type: protein coding

About SSX5

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,186,220-48,196,795 (from NCBI)

This gene has 3 transcripts (splice variants), 102 orthologues and 7 paralogues. Low expression observed in reference dataset.

Summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in Cancer patients, and are potentially useful targets in Cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2013]

SSX5 Products(2)

mRNA Protein Name
NM_021015.4 NP_066295.3 protein SSX5 isoform a
NM_175723.2 NP_783729.1 protein SSX5 isoform b

SSX5 Protein Structure

SSXRD

SSXRD: SSXRD motif (155 - 188)

  • 0
  • 100
  • 188 a.a.
Protein Preferred Names Protein Names

protein SSX5

synovial sarcoma, X breakpoint 5

Related Diseases

Diseases Alias
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Sarcoma, Synovial

Synovial Sarcoma

Synovialosarcoma

Synovial Cell Sarcoma

Sarcoma Synovial

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma