Necap1 - NECAP endocytosis associated 1 Gene

Mus musculus

Also known as 1200016B17Rik

Gene ID: 67602 | Gene type: protein coding

About Necap1

Summary

Involved in endocytosis. Located in clathrin-coated pit. Part of clathrin vesicle coat. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 21. Orthologous to human NECAP1 (NECAP endocytosis associated 1). [provided by Alliance of Genome Resources, Apr 2022]

Necap1 Products(1)

mRNA	Protein	Name
NM_026267.3	NP_080543.2	adaptin ear-binding coat-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14555962	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	14555962	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of clathrin vesicle coat	IDA IDA: Inferred from direct assay	14555962	MGI
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	14555962	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adaptin ear-binding coat-associated protein 1

NECAP endocytosis-associated protein 1	brain enriched NECAP2 similar protein
clathrin-coated vesicle coat protein	snoRNA MBI-129

Necap1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Necap1	Q9CR95	SNAP91	Homo sapiens	O60641	Pull Down	17762867
Intra	Necap1	Q9CR95	Dab2	Mus musculus	P98078	Pull Down	17762867
Intra	Necap1	Q9CR95	Fcho1	Mus musculus	Q8K285	Pull Down	24130457
Cross	Necap1	Q9CR95	AMPH	Homo sapiens	P49418	Pull Down	17762867
Cross	Necap1	Q9CR95	AMPH	Homo sapiens	P49418	Competition Binding	17762867
Cross	Necap1	Q9CR95	Amph	Rattus norvegicus	O08838	Pull Down	17762867
Cross	Necap1	Q9CR95	Amph	Rattus norvegicus	O08838	Pull Down	24130457
Cross	Necap1	Q9CR95	Bin1	Rattus norvegicus	O08839	Pull Down	24130457
Cross	Necap1	Q9CR95	Bin1	Rattus norvegicus	O08839	Pull Down	17762867
Cross	Necap1	Q9CR95	Bin1	Rattus norvegicus	O08839	Competition Binding	17762867

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09172	NECAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Necap1	NCBI	NCBI:25977

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