Kirrel3 - kirre like nephrin family adhesion molecule 3 Gene

Mus musculus

Also known as SST4; NEPH2; mKIAA1867; 1500010O20Rik; 2900036G11Rik

Gene ID: 67703 | Gene type: protein coding

About Kirrel3

Summary

Predicted to enable cell adhesion molecule binding activity. Involved in hemopoiesis; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Acts upstream of or within glomerulus morphogenesis; inter-male aggressive behavior; and nervous system development. Located in several cellular components, including axon; dendritic shaft; and extracellular region. Is integral component of membrane. Is expressed in central nervous system; dorsal root ganglion; glomerular tuft; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 4. Orthologous to human KIRREL3 (kirre like nephrin family adhesion molecule 3). [provided by Alliance of Genome Resources, Apr 2022]

Kirrel3 Products(5)

mRNA	Protein	Name
NM_001190911.1	NP_001177840.1	kin of IRRE-like protein 3 isoform A precursor
NM_001190912.1	NP_001177841.1	kin of IRRE-like protein 3 isoform C precursor
NM_001190913.1	NP_001177842.1	kin of IRRE-like protein 3 isoform D precursor
NM_001190914.1	NP_001177843.1	kin of IRRE-like protein 3 isoform E
NM_026324.3	NP_080600.1	kin of IRRE-like protein 3 isoform B precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16874800	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within glomerulus morphogenesis	IMP IMP: Inferred from mutant phenotype	23637329	MGI
involved in hemopoiesis	IDA IDA: Inferred from direct assay	12665856	MGI
involved in hippocampus development	IMP IMP: Inferred from mutant phenotype	26575286	MGI
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	26575286	MGI
acts upstream of or within inter-male aggressive behavior	IMP IMP: Inferred from mutant phenotype	23637329	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	21241806	MGI
acts upstream of or within neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	23637329	MGI
acts upstream of or within principal sensory nucleus of trigeminal nerve development	IMP IMP: Inferred from mutant phenotype	21241806	MGI
involved in synapse assembly	IDA IDA: Inferred from direct assay	26575286	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	16874800	MGI
located in dendrite	IDA IDA: Inferred from direct assay	26575286	MGI
located in dendritic shaft	IDA IDA: Inferred from direct assay	16874800	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	12665856	MGI
located in membrane	IDA IDA: Inferred from direct assay	12665856	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12665856	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

kin of IRRE-like protein 3

X kin of IRRE like 3	kin of IRRE like 3
kin of irregular chiasm-like protein 3	membrane protein mKirre
nephrin-like protein 2

Recombinant Kirrel3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77045	KIRREL3/NEPH2 Protein, Mouse (HEK293, His)	Q8BR86 (L22-A535)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07314	KIRREL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kirrel3	NCBI	NCBI:84623
Rattus norvegicus	Kirrel3	NCBI	NCBI:315546

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