ZFP36L2 - ZFP36 ring finger protein like 2 Gene

Homo sapiens

Also known as BRF2; ERF2; ERF-2; OOMD13; TIS11D; RNF162C

Gene ID: 678 | Gene type: protein coding

About ZFP36L2

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:43,222,402-43,226,606 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 108.0), appendix (RPKM 94.7) and 25 other tissues.

Summary

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]

ZFP36L2 Products(1)

mRNA	Protein	Name
NM_006887.5	NP_008818.3	mRNA decay activator protein ZFP36L2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	20506496	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25106868	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA destabilization	IMP IMP: Inferred from mutant phenotype	25106868	GOA
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	25106868	GOA
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to fibroblast growth factor stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to glucocorticoid stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	20166898	GOA
involved in mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	34611029	GOA
involved in regulation of mRNA stability	IMP IMP: Inferred from mutant phenotype	25106868	GOA
involved in response to wounding	IDA IDA: Inferred from direct assay	27182009	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFP36L2 Protein Structure

Tis11B_N

zf-CCCH

0
100
200
300
400
494 a.a.

Protein Preferred Names

Protein Names

mRNA decay activator protein ZFP36L2

EGF-response factor 2

ZFP36L2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZFP36L2	P47974	YWHAE	Homo sapiens	P62258	Crosslink	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Achromatopsia 7

ACHM7

Achromatopsia, Type 7

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16042	ZFP36L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZFP36L2	RGD	RGD:1308913
Macaca mulatta	ZFP36L2	VGNC	VGNC:106246
Bos taurus	ZFP36L2	VGNC	VGNC:54514
Canis familiaris	ZFP36L2	VGNC	VGNC:48614
Mus musculus	ZFP36L2	MGD	MGI:107945

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