2. Gene
  3. SULT1E1 - sulfotransferase family 1E member 1 Gene

SULT1E1 - sulfotransferase family 1E member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EST; STE; EST-1; ST1E1

Gene ID: 6783 | Gene type: protein coding

About SULT1E1

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:69,821,122-69,860,145 (from NCBI)

This gene has 2 transcripts (splice variants), 616 orthologues and 12 paralogues. Biased expression in small intestine (RPKM 11.9), duodenum (RPKM 11.7) and 4 other tissues.

Summary

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]

SULT1E1 Products(1)

mRNA Protein Name
NM_005420.3 NP_005411.1 sulfotransferase 1.00E+01
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables flavonol 3-sulfotransferase activity IDA
IDA: Inferred from direct assay
20056724 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables steroid sulfotransferase activity IDA
IDA: Inferred from direct assay
11884392 GOA
enables sulfotransferase activity IDA
IDA: Inferred from direct assay
19548878 GOA
Biological Process GO Annotation Evidence Reference Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
IDA: Inferred from direct assay
23207770 GOA
involved in estrogen catabolic process IDA
IDA: Inferred from direct assay
23207770 GOA
involved in estrogen metabolic process IDA
IDA: Inferred from direct assay
11884392 GOA
involved in ethanol catabolic process IDA
IDA: Inferred from direct assay
23207770 GOA
involved in positive regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
24567372 GOA
acts upstream of or within sulfation IDA
IDA: Inferred from direct assay
19548878 GOA
involved in sulfation IDA
IDA: Inferred from direct assay
20056724 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT1E1 Protein Structure

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (37 - 286)

  • 0
  • 100
  • 200
  • 294 a.a.
Protein Preferred Names Protein Names

sulfotransferase 1E1

estrogen sulfotransferase

SULT1E1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SULT1E1 P49888 PDE9A Homo sapiens O76083-2
Y2H Prey Pooling
32296183
Intra
SULT1E1 P49888 PDE9A Homo sapiens O76083-2
Y2H Array
32296183
Intra
SULT1E1 P49888 PDE9A Homo sapiens O76083
Validated Y2H
25416956
Intra
SULT1E1 P49888 PDE9A Homo sapiens O76083
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SULT1E1 Proteins

Cat. No. Product Name Accession Purity
HY-P76099 SULT1E1 Protein, Human (His) P49888 (N2-I294) ≥95%

Related Diseases

Diseases Alias
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Skin Angiosarcoma

Angiosarcoma Of Skin

Hemangiosarcoma Of The Skin

Haemangiosarcoma Of Skin

Lymphangiosarcoma Of Skin

Cutaneous Angiosarcoma

Malignant Haemangioendothelioma Of Skin
Estrogen Excess

Hyperestrogenism
Clear Cell Adenoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Breast Disease

Breast Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14019 SULT1E1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SULT1E1 MGD MGI:98431
Rattus norvegicus SULT1E1 RGD RGD:3776
Macaca mulatta SULT1E1 VGNC VGNC:100275
Bos taurus SULT1E1 VGNC VGNC:35467
Others SULT1E1 NCBI