SUPT6H - SPT6 homolog, histone chaperone and transcription elongation factor Gene

Homo sapiens

Also known as SPT6; SPT6H; emb-5

Gene ID: 6830 | Gene type: protein coding

About SUPT6H

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,662,205-28,702,679 (from NCBI)

This gene has 12 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in bone marrow (RPKM 15.3), ovary (RPKM 14.3) and 25 other tissues.

Summary

Enables histone binding activity. Involved in negative regulation of histone H3-K27 methylation and positive regulation of transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. Predicted to be active in transcriptionally active chromatin. [provided by Alliance of Genome Resources, Apr 2022]

SUPT6H Products(4)

mRNA	Protein	Name
NM_001320755.2	NP_001307684.1	transcription elongation factor SPT6
NM_003170.5	NP_003161.2	transcription elongation factor SPT6
NM_001320755.2	NP_001307684.1	transcription elongation factor SPT6
NM_003170.5	NP_003161.2	transcription elongation factor SPT6

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone binding	IDA IDA: Inferred from direct assay	10933715	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10933715	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17234882	GOA
involved in transcription elongation-coupled chromatin remodeling	IMP IMP: Inferred from mutant phenotype	23503590	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUPT6H Protein Structure

SPT6_acidic

HTH_44

YqgF

HHH_7

DLD

SH2_2

0
300
600
900
1200
1500
1726 a.a.

Protein Preferred Names

Protein Names

transcription elongation factor SPT6

histone chaperone suppressor of Ty6

Related Diseases

Diseases

Alias

Ichthyosis, Congenital, Autosomal Recessive 11

Autosomal Recessive Congenital Ichthyosis 11	Ichthyosis With Hypotrichosis, Autosomal Recessive
Arih	Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis
Autosomal Recessive Ichthyosis With Hypotrichosis	ARCI11
Ifah	Hypotrichosis-Congenital Ichthyosis Syndrome
Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome	Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome
Ichthyosis-Hypotrichosis Syndrome	Ifah Syndrome
Ihs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14039	SUPT6H Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SUPT6H	RGD	RGD:1309290
Mus musculus	SUPT6H	MGD	MGI:107726
Macaca mulatta	SUPT6H	VGNC	VGNC:78057
Canis familiaris	SUPT6H	VGNC	VGNC:49096
Bos taurus	SUPT6H	VGNC	VGNC:50619
Felis catus	SUPT6H	VGNC	VGNC:65850

Name
Email *

	Sorry, but the email address you supplied was invalid.