KLF9 - KLF transcription factor 9 Gene

Homo sapiens

Also known as BTEB; BTEB1

Gene ID: 687 | Gene type: protein coding

About KLF9

Cytogenetic location: 9q21.12 Genomic coordinates (GRCh38): 9:70,384,604-70,414,657 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues and 22 paralogues. Ubiquitous expression in fat (RPKM 44.7), gall bladder (RPKM 34.1) and 25 other tissues.

Summary

The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]

KLF9 Products(1)

mRNA	Protein	Name
NM_001206.4	NP_001197.1	Krueppel-like factor 9

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cortisol stimulus	IDA IDA: Inferred from direct assay	22711835	GOA
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	22711835	GOA
involved in negative regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	22711835	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	22711835	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF9 Protein Structure

zf-H2C2_2

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

Krueppel-like factor 9

BTE-binding protein 1

Related Diseases

Diseases

Alias

Otosclerosis

Otospongiosis

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07346	KLF9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KLF9	RGD	RGD:70934
Felis catus	KLF9	VGNC	VGNC:102943
Canis familiaris	KLF9	VGNC	VGNC:53731
Mus musculus	KLF9	MGD	MGI:1333856
Bos taurus	KLF9	VGNC	VGNC:30632

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