2. Gene
  3. TAF2 - TATA-box binding protein associated factor 2 Gene

TAF2 - TATA-box binding protein associated factor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MRT40; TAF2B; CIF150; TAFII150

Gene ID: 6873 | Gene type: protein coding

About TAF2

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,730,774-119,832,841 (from NCBI)

This gene has 43 transcripts (splice variants), 207 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 8.1), lymph node (RPKM 6.4) and 25 other tissues.

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]

TAF2 Products(1)

mRNA Protein Name
NM_003184.4 NP_003175.2 transcription initiation factor TFIID subunit 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9418870 GOA
enables transcription cis-regulatory region binding IMP
IMP: Inferred from mutant phenotype
10409744 GOA
Biological Process GO Annotation Evidence Reference Source
involved in G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
10409744 GOA
involved in RNA polymerase II preinitiation complex assembly IPI
IPI: Inferred from physical interaction
27007846 GOA
involved in mRNA transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17884155 GOA
involved in positive regulation of transcription initiation by RNA polymerase II IDA
IDA: Inferred from direct assay
17884155 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9603525 GOA
involved in transcription initiation at RNA polymerase II promoter IDA
IDA: Inferred from direct assay
9418870 GOA
involved in transcription initiation at RNA polymerase II promoter IMP
IMP: Inferred from mutant phenotype
10409744 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus EXP
EXP: Inferred from Experiment
23332750 GOA
part of transcription factor TFIID complex IDA
IDA: Inferred from direct assay
9774672 GOA
part of transcription factor TFIID complex IPI
IPI: Inferred from physical interaction
23332750 GOA
part of transcription factor TFTC complex IDA
IDA: Inferred from direct assay
10373431 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF2 Protein Structure

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (27 - 390)

  • 0
  • 200
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  • 800
  • 1000
  • 1199 a.a.
Protein Preferred Names Protein Names

transcription initiation factor TFIID subunit 2

150 kDa cofactor of initiator function

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Feeding Difficulties, Thin Corpus Callosum, And Foot Deformity

Microcephaly-Thin Corpus Callosum-Intellectual Disability Syndrome

NEDFCF

Mrt40

Mental Retardation, Autosomal Recessive 40

Intellectual Developmental Disorder, Autosomal Recessive 40

Autosomal Recessive Intellectual Developmental Disorder 40

Mental Retardation, Autosomal Recessive, Type 40
Dystonia 3, Torsion, X-Linked

X-Linked Dystonia-Parkinsonism

DYT3

Xdp

Lubag

Dystonia-Parkinsonism, X-Linked

Torsion Dystonia-Parkinsonism, Filipino Type

Dyt-Taf1

X-Linked Dystonia-Parkinsonism Syndrome

X-Linked Torsion Dystonia-Parkinsonism Syndrome

Dystonia Musculorum Deformans

X-Linked Dystonia-Parkinsonism/Lubag

Lubag Syndrome

Dystonia-3

Torsion Dystonia-Parkinsonism Filipino Type

X-Linked Torsion Dystonia 3

Dystonia, Torsion, X-Linked, Type 3
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14167 TAF2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TAF2 MGD MGI:2443028
Canis familiaris TAF2 VGNC VGNC:47080
Felis catus TAF2 VGNC VGNC:65930
Macaca mulatta TAF2 VGNC VGNC:78090
Rattus norvegicus TAF2 RGD RGD:621487
Bos taurus TAF2 VGNC VGNC:35573
Others TAF2 NCBI