TCN2 - transcobalamin 2 Gene

Homo sapiens

Also known as II; TC; TC2; TC-2; TCII; TC II; D22S676; D22S750

Gene ID: 6948 | Gene type: protein coding

About TCN2

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,607,174-30,627,271 (from NCBI)

This gene has 18 transcripts (splice variants), 197 orthologues, 2 paralogues and is associated with 3 phenotypes. Broad expression in kidney (RPKM 50.7), gall bladder (RPKM 33.1) and 22 other tissues.

Summary

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R Binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and Other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

TCN2 Products(2)

mRNA	Protein	Name
NM_000355.4	NP_000346.2	transcobalamin-2 isoform 1 precursor
NM_001184726.2	NP_001171655.1	transcobalamin-2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cargo receptor ligand activity	EXP EXP: Inferred from Experiment	3782074	GOA
enables cobalamin binding	IDA IDA: Inferred from direct assay	8443384	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27411955	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cobalamin transport	IDA IDA: Inferred from direct assay	8443384	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	8443384	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCN2 Protein Structure

Cobalamin_bind

DUF4430

0
100
200
300
400
427 a.a.

Protein Preferred Names

Protein Names

transcobalamin-2

macrocytic anemia

TCN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TCN2	P20062	CD320	Homo sapiens	Q9NPF0	ELISA	27411955
Intra	TCN2	P20062	CD320	Homo sapiens	Q9NPF0	ITC	27411955
Intra	TCN2	P20062	CD320	Homo sapiens	Q9NPF0	X-Ray Diffraction	27411955
Intra	TCN2	P20062	CD320	Homo sapiens	Q9NPF0	GMS	27411955
Intra	TCN2	P20062	CD320	Homo sapiens	Q9NPF0	Crosslink	27411955

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Transcobalamin Ii Deficiency

TCN2 DEFICIENCY	Tc Ii Deficiency
Transcobalamin Deficiency	Tc Deficiency
Inherited Deficiency Of Transcobalamin

Pancytopenia

Vitamin B12 Deficiency

Cobalamin Deficiency	Hypocobalaminemia
Vitamin B 12 Deficiency	Cyanocobalamin Deficiency
Deficiency Of Vitamin B12

Homocystinuria

Cystathionine Beta Synthase Deficiency	Homocysteinemia
Cbs Deficiency	Cystathionine Synthase Deficiency
Cystathionine Beta-Synthase Deficiency Disease

Megaloblastic Anemia

Imerslund-Grasbeck Syndrome	Igs
Defect Of Enterocyte Intrinsic Factor Receptor	Enterocyte Cobalamin Malabsorption
Familial Megaloblastic Anemia	Megaloblastic Anemia 1
Selective Cobalamin Malabsorption With Proteinuria	Imerslund-Gräsbeck Syndrome
Anemia, Megaloblastic	Grasbeck-Imerslund Syndrome
Megaloblastic Anaemia	Mga1 Norwegian Type
Recessive Hereditary Megaloblastic Anaemia 1	Recessive Hereditary Megaloblastic Anemia 1
Rh-Mga1	Gräsbeck-Imerslund Disease
Pernicious Anemia, Juvenile, Due To Selective Intestinal Malabsorption Of Vitamin B12, With Proteinuria	Juvenile Pernicious Anemia With Proteinuria Due To Selective Intestinal Malabsorption Of Vitamin B12
Anemia Megaloblastic	Megaloblastic Anemia Due To Inborn Errors Of Metabolism
3-@Methylglutaconic Aciduria, Type I

Vitamin Metabolic Disorder

Methylmalonic Acidemia

Methylmalonic Aciduria	Mma
Acidemia, Methylmalonic	Isolated Methylmalonic Acidemia

Macrocytic Anemia

Anemia Macrocytic	Anemia, Macrocytic
Macrocytic Anaemia

Megaesophagus

Esophageal Achalasia

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Epidemic Typhus

Typhus	Typhus Fever
Epidemic Louse-Borne Typhus Fever Due To Rickettsia Prowazekii	Murine Typhus
Classical Typhus	Endemic Flea-Borne Typhus
Endemic Typhus Fever	Epidemic Louse-Borne Typhus
Famine Fever	Flea-Borne Typhus
Jail Fever	Louse-Borne Typhus
Mexican Typhus	Shop Typhus
Urban Typhus	Brill-Zinsser Disease
Endemic Typhus	Sylvatic Typhus
Epidemic Typhus	European Typhus
Exanthematic Typhus Fever	Exanthematous Typhus
Flea Typhus	Flea-Borne Rickettsiosis
Hospital Fever	Louse-Borne [Epidemic] Typhus
Louse-Borne Rickettsiosis	Moscow Typhus
Murine [Endemic] Typhus	Petechial Fever
Prison Fever	Rat Flea Typhus
Ship Fever	Typhus Exanthematique
Typhus, Endemic Flea-Borne	Typhus, Epidemic Louse-Borne
Typhus Group Rickettsial Disease	Relapsing Fever
Typhus Fever Nos	Typhus Nos
Epidemic Typhus Fever	Louse-Borne Typhus Fever
Classical Typhus Fever	Louse-Borne Tabardillo
Epidemic Typhus Fever Due To Rickettsia Prowazekii	Endemic Murine Typhus
Flea-Borne Typhus Fever	Murine Endemic Flea Typhus
Rat Typhus	Typhus Due To Rickettsia Typhi
Flea-Borne Tabardillo	Rickettsia Typhi Rickettsiosis
Mexican Fever	Murine Flea-Borne Typhus
Mooser Bodies	Tsutsugamushi Fever
Kedani Fever	Mite-Borne Typhus
Mite-Borne Typhus Due To Rickettsia Tsutsugamushi	Scrub Typhus
Tsutsugamushi	Tsutsugamushi Disease
Scrub Mite-Borne Typhus	Sumatran Mite Fever
Japanese River Fever	Kedani Typhus
Rickettsia Tsutsugamushi Rickettsiosis	Sumatran Mite Typhus
Tropical Typhus	Japanese Typhus

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Mobitz Type Ii Atrioventricular Block

Mobitz Ii Atrioventricular Block

Scrub Typhus

Tsutsugamushi Disease	Tsutsugamushi Fever
Typhus Fever Due To Rickettsia Tsutsugamushi	Chigger-Borne Rickettsiosis
Chigger-Borne Typhus	Japanese River Fever
Kedani Fever	Mite-Borne Rickettsiosis
Mite-Borne Typhus	Scrub Typhus
Scrub Mite-Borne Typhus	Tropical Typhus
Tsutsugamushi

Anal Gland Adenocarcinoma

Adenocarcinoma Of Anal Ducts	Adenocarcinoma Of Anal Gland
Anal Glands Adenocarcinoma	Adenocarcinoma Of Anal Glands

Fasciolopsiasis

Infection By Fasciolopsis Buski	Infectious Disease By Fasciolopsis
Intestinal Distomatosis	Intestinal Distoma
Giant Intestinal Fluke Infection	Fasciolopsis Buski Infection
Infection By Fasciolopsis	Busk Fluke Infection
Intestinal Fluke Infestation	Infestation By Fasciolopsis
Intestinal Distomiasis	Intestinal Fluke Disease
Intestinal Fluke Infection

Pernicious Anemia

Anemia, Pernicious	Anemia Pernicious
Pernicious Anaemia	Addison'S Anaemia
Biermer'S Anaemia	Biermer'S Anemia
Acquired Pernicious Anemia	Addison-Biermer Anemia
Addisonian Anemia	Biermer Anemia
Biermer'S Disease	Juvenile Onset Pernicious Anemia
Biermer Disease	Biermer-Addison Disease

Typhoid Fever

Typhoid	Enteric Fever
Typhoidal Salmonellosis	Ileotyphus
Infection By Salmonella Typhi	Typhoid Any Site
Typhoid Fever Any Site	Typhoid Infection
Typhoid Infection Any Site	Typhoid Fever Confirmed
Enteric Fever Nos

Anus Adenocarcinoma

Adenocarcinoma Of Anus

Adenocarcinoma Of The Anus

Cerebrovascular Disease

Cerebrovascular Disorder	Cerebrovascular Accident
Cerebrovascular Disorders	Cva
Stroke

Septal Myocardial Infarction

Colon Adenocarcinoma

Adenocarcinoma Of Colon	Adenocarcinoma Of The Colon
Colonic Adenocarcinoma

Parasitic Protozoa Infectious Disease

Protozoan Infections	Mastigophora Infectious Disease
Sarcomastigophora Infectious Disease

Trypanosomiasis

Toxocariasis

Toxocara Infection	Visceral Larva Migrans
Larva Migrans, Visceral	Infection By Toxascaris
Larva Migrans Visceral	Larva Migrans Visceralis
Toxocaral Visceral Larva Migrans	Visceral Larva Migrans Syndrome
Toxocara Infestation

Rapp-Hodgkin Syndrome

RHS	Anhidrotic Ectodermal Dysplasia With Cleft Lip/Palate
Ectodermal Dysplasia, Rapp-Hodgkin Type	Rapp-Hodgkin Ectodermal Dysplasia Syndrome
Ectodermal Dysplasia, Anhidrotic, With Cleft Lip/Palate	Ectodermal Dysplasia Syndrome, Rapp-Hodgkin Type
Edrh	Rapp-Hodgkin Ectodermal Dysplasia
Orofacial Cleft 8

Glossitis

Inflammation Of Tongue	Tongue Inflammation
Glazed Tongue

Spleen Angiosarcoma

Angiosarcoma Of Spleen

Splenic Hemangiosarcoma

Megacolon

Dilatation Of Colon

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14319	TCN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TCN2	VGNC	VGNC:66033
Canis familiaris	TCN2	VGNC	VGNC:47205
Rattus norvegicus	TCN2	RGD	RGD:620681
Mus musculus	TCN2	MGD	MGI:98534
Bos taurus	TCN2	VGNC	VGNC:35699
Macaca mulatta	TCN2	VGNC	VGNC:78293
Others	TCN2	NCBI