TRB - T cell receptor beta locus Gene

Homo sapiens

Also known as TCRB; TRB@

Gene ID: 6957 | Gene type: protein coding

About TRB

Summary

T cell receptors recognize foreign antigens which have been processed as small Peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables signaling receptor activity	IDA IDA: Inferred from direct assay	31959982	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell mediated cytotoxicity directed against tumor cell target	IDA IDA: Inferred from direct assay	31959982	GOA
involved in detection of tumor cell	IDA IDA: Inferred from direct assay	31959982	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of alpha-beta T cell receptor complex	IDA IDA: Inferred from direct assay	31959982	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases

Alias

Trypsinogen Deficiency

Pancreatic Trypsinogen Deficiency

Vitamin D-Dependent Rickets, Type 2a

Hvdrr	Generalized Resistance To 1,25-Dihydroxyvitamin D
Hypocalcemic Vitamin D-Resistant Rickets	VDDR2A
Rickets, Hereditary Vitamin D-Resistant	Vitamin D-Resistant Rickets With End-Organ Unresponsiveness To 1,25-Dihydroxycholecalciferol
Pddr Iia	Rickets-Alopecia Syndrome
Rickets, Vitamin D-Resistant, Type Iia	Vitamin D-Dependent Rickets Type 2a
Vitamin D-Dependent Rickets, Type 2	Vitamin D-Dependent Rickets, Type 2a, With Or Without Alopecia
Generalized 1,25-Dihydroxyvitamin D	Pseudovitamin D-Deficiency, Type Iia
Hereditary Vitamin D-Resistant Rickets	Vddr Ii
Vdrr Ii	Vitamin D-Dependent Rickets Type Ii
Vitamin D-Resistant Rickets Type Ii	Rickets Vitamin D-Dependent 2a
Pseudovitamin D-Deficiency Type Iia	Rickets Hereditary Vitamin D-Resistant
Type Iia Rickets	Vitamin D-Dependent Rickets Type 2a With Or Without Alopecia
Vitamin D-Dependent Rickets, Type Ii	Familial Hypophosphatemic Rickets
Hypophosphatemic Rickets, X-Linked Dominant

Prss1-Related Hereditary Pancreatitis

Pancreatitis, Hereditary

Hereditary Pancreatitis	Chronic Pancreatitis
Hereditary Chronic Pancreatitis	Hp
Pancreatitis, Chronic, Susceptibility To	PCTT
Hpc	Pancreatitis, Chronic
Pancreatitis, Chronic, Protection Against	Autosomal Dominant Hereditary Pancreatitis
Familial Pancreatitis	Cp
Pancreatitis Hereditary

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Granulomatous Slack Skin Disease

Granulomatous Slack Skin

B-Cell Expansion With Nfkb And T-Cell Anergy

Benta Disease	BENTA
B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease	Persistent Polyclonal B-Cell Lymphocytosis
Lymphocytosis

T-Cell Large Granular Lymphocyte Leukemia

Large Granular Lymphocytic Leukemia	Proliferation Of Large Granular Lymphocytes
T-Lgl	T-Cell Lgl Leukemia
Large Granular Lymphocytic Leukaemia	T-Cell Large Granular Lymphocyte Leukaemia
Large Cell Granular Lymphogenous Leukemia	T-Lgl Leukemia
Leukemia Lymphocytic Large Granular	Leukemia, Large Granular Lymphocytic

Thymoma

Primary Thymic Epithelial Neoplasm	Primary Thymic Epithelial Tumor
Thymus Neoplasms

Reticulosarcoma

Histiocytic Lymphoma	Large-Cell Lymphomas
Lymphoma, Large-Cell	Lymphoma Large Cell
Diffuse Large B-Cell Lymphoma	Histiocytic Sarcoma

Pleurisy

Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis	Juvenile Chronic Polyarthritis
Monarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Arthritis
Still'S Disease	Systemic Juvenile Rheumatoid Arthritis
Juvenile Chronic Arthritis	Acute Juvenile Rheumatoid Arthritis
Pauciarticular Onset Juvenile Chronic Arthritis	Arthritis, Juvenile Rheumatoid
Jia	Jra
Juvenile Ra	Arthritis Juvenile Rheumatoid
Stills Disease	Juvenile Arthritis
Acute Polyarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis, Systemic Juvenile

Relapsing-Remitting Multiple Sclerosis

Relapsing-Remitting Ms	Relapsing Remitting Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting	Rrms
Multiple Sclerosis Relapsing-Remitting

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

Cutaneous T-Cell Lymphoma	Cutaneous T Cell Lymphoma
Lymphoma, T-Cell, Cutaneous	Ctcl
Lymphoma T-Cell Cutaneous

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y1309	1-Naphthol		99.96%	Unkown
HY-120793	CMC2.24		97.48%	Unkown
HY-RS14997	TRB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-Y1309S	1-Naphthol-d8		/	Unkown
HY-Y1309S1	1-Naphthol-d7		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRB	NCBI

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