Lrfn2 - leucine rich repeat and fibronectin type III domain containing 2 Gene

Mus musculus

Also known as SALM1; mKIAA1246; 5730420O05Rik

Gene ID: 70530 | Gene type: protein coding

About Lrfn2

Summary

Involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Located in Schaffer collateral - CA1 synapse and cell surface. Is expressed in several structures, including central nervous system; esophagus; eye; male reproductive gland or organ; and trigeminal nerve. Used to study autism spectrum disorder. Orthologous to human LRFN2 (leucine rich repeat and fibronectin type III domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrfn2 Products(1)

mRNA	Protein	Name
NM_027452.3	NP_081728.2	leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16495444	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	28604739	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	28604739	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	28604739	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	28604739	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	28604739	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	28604739	MGI
located in cell surface	IDA IDA: Inferred from direct assay	16828986	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	31368584	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	31368584	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leucine-rich repeat and fibronectin type-III domain-containing protein 2

Lrfn2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Lrfn2	Q80TG9	Dlg4	Mus musculus	Q62108	Anti Tag CoIP	28604739
Intra	Lrfn2	Q80TG9	Dlg4	Mus musculus	Q62108	Anti Tag CoIP	16495444
Intra	Lrfn2	Q80TG9	Dlg1	Mus musculus	Q811D0	Anti Tag CoIP	16495444
Intra	Lrfn2	Q80TG9	Dlg1	Mus musculus	Q811D0	Anti Bait CoIP	16495444

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07782	LRFN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrfn2	NCBI	NCBI:57497

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