P2ry12 - purinergic receptor P2Y, G-protein coupled 12 Gene

Mus musculus

Also known as P2Y12; 2900079B22Rik; 4921504D23Rik

Gene ID: 70839 | Gene type: protein coding

About P2ry12

Chromosome 3: 59,123,693-59,170,292 reverse strand.GRCm39:CM000996.3

This gene has 5 transcripts (splice variants), 182 orthologues, 6 paralogues and is associated with 5 phenotypes. Broad expression in cortex adult (RPKM 1.9), frontal lobe adult (RPKM 1.2) and 15 other tissues.

Summary

Enables G protein-coupled ADP receptor activity and G protein-coupled Adenosine Receptor activity. Involved in several processes, including cellular response to ATP; regulation of microglial cell migration; and substrate-dependent cell migration, cell extension. Acts upstream of or within several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; platelet activation; and positive regulation of ion transport. Located in cell body membrane and cell projection membrane. Is expressed in central nervous system and cerebral cortex. Used to study platelet-type bleeding disorder 8. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Apr 2022]

P2ry12 Products(4)

mRNA	Protein	Name
NM_001357010.1	NP_001343939.1	P2Y purinoceptor 12
NM_027571.4	NP_081847.3	P2Y purinoceptor 12
NM_001357008.1	NP_001343937.1	P2Y purinoceptor 12
NM_001357007.1	NP_001343936.1	P2Y purinoceptor 12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled ADP receptor activity	IMP IMP: Inferred from mutant phenotype	11413167	MGI
enables G protein-coupled adenosine receptor activity	IMP IMP: Inferred from mutant phenotype	11413167	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11413167	MGI
involved in cellular response to ATP	IMP IMP: Inferred from mutant phenotype	17115040	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	23479225	MGI
acts upstream of establishment of localization in cell	IGI IGI: Inferred from genetic interaction	15914557	MGI
acts upstream of monoatomic ion transport	IGI IGI: Inferred from genetic interaction	15914557	MGI
acts upstream of or within platelet activation	IMP IMP: Inferred from mutant phenotype	11413167	MGI
acts upstream of or within positive regulation of monoatomic ion transport	IGI IGI: Inferred from genetic interaction	15914557	MGI
involved in regulation of microglial cell migration	IDA IDA: Inferred from direct assay	17115040	MGI
involved in substrate-dependent cell migration, cell extension	IMP IMP: Inferred from mutant phenotype	17115040	MGI
involved in visual system development	IGI IGI: Inferred from genetic interaction	26948129	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body membrane	IGI IGI: Inferred from genetic interaction	26948129	MGI
located in cell projection membrane	IGI IGI: Inferred from genetic interaction	26948129	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17115040	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2ry12 Protein Structure

7tmA_P2Y12

0
100
200
300
347 a.a.

Protein Preferred Names

Protein Names

P2Y purinoceptor 12

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09919	P2RY12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09920	P2ry12 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09921	P2ry12 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2ry12	NCBI	NCBI:64805

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