C1QB - complement C1q B chain Gene

Homo sapiens

Gene ID: 713 | Gene type: protein coding

About C1QB

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,653,236-22,661,637 (from NCBI)

This gene has 13 transcripts (splice variants), 145 orthologues, 23 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 482.2), lymph node (RPKM 181.6) and 15 other tissues.

Summary

This gene encodes the B-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum Complement System. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]

C1QB Products(3)

mRNA	Protein	Name
NM_000491.5	NP_000482.3	complement C1q subcomponent subunit B isoform 1 precursor
NM_001371184.3	NP_001358113.2	complement C1q subcomponent subunit B isoform 2 precursor
NM_001378156.1	NP_001365085.1	complement C1q subcomponent subunit B isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7240	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in complement activation, classical pathway	IDA IDA: Inferred from direct assay	29449492	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of complement component C1q complex	IPI IPI: Inferred from physical interaction	29449492	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	18250442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QB Protein Structure

Collagen

C1q

0
100
200
253 a.a.

Protein Preferred Names

Protein Names

complement C1q subcomponent subunit B

complement C1q chain B

Recombinant C1QB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75464	C1QB Protein, Human (sf9, His)	P02746 (Q28-A253)	≥95%

Related Diseases

Diseases

Alias

C1q Deficiency

C1QD	Complement Component C1q Deficiency

Immunodeficiency Due To A Classical Component Pathway Complement Deficiency

Immunodeficiency Due To C1, C4, Or C2 Component Complement Deficiency

Immunodeficiency Due To An Early Component Of Complement Deficiency

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Glomerulonephritis

Bright'S Disease

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01719	C1QB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	C1QB	MGD	MGI:88224
Canis familiaris	C1QB	VGNC	VGNC:38577
Macaca mulatta	C1QB	VGNC	VGNC:106331
Felis catus	C1QB	VGNC	VGNC:60220
Rattus norvegicus	C1QB	RGD	RGD:2229
Bos taurus	C1QB	VGNC	VGNC:26617
Others	C1QB	NCBI

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