TNNC1 - troponin C1, slow skeletal and cardiac type Gene

Homo sapiens

Also known as TNC; TN-C; TNNC; CMD1Z; CMH13

Gene ID: 7134 | Gene type: protein coding

About TNNC1

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,451,100-52,454,041 (from NCBI)

This gene has 3 transcripts (splice variants), 207 orthologues, 1 paralogue and is associated with 5 phenotypes. Restricted expression toward heart (RPKM 1964.8).

Summary

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with Myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

TNNC1 Products(1)

mRNA	Protein	Name
NM_003280.3	NP_003271.1	troponin C, slow skeletal and cardiac muscles

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	12840750	GOA
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	7957210	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10806205	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18092822	GOA
enables troponin I binding	IDA IDA: Inferred from direct assay	18092822	GOA
enables troponin I binding	IPI IPI: Inferred from physical interaction	7957210	GOA
enables troponin T binding	IPI IPI: Inferred from physical interaction	8205619	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac muscle contraction	IDA IDA: Inferred from direct assay	25771144	GOA
involved in cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	15542288	GOA
involved in regulation of muscle contraction	IDA IDA: Inferred from direct assay	18092822	GOA
involved in ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	15542288	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cardiac Troponin complex	IDA IDA: Inferred from direct assay	25771144	GOA
part of troponin complex	IDA IDA: Inferred from direct assay	10850966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNNC1 Protein Structure

EF-hand_8

EF-hand_7

0
100
161 a.a.

Protein Preferred Names

Protein Names

troponin C, slow skeletal and cardiac muscles

cardiac troponin C

TNNC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNNC1	P63316	TNNI3	Homo sapiens	P19429	X-Ray Diffraction	12840750
Intra	TNNC1	P63316	TNNI2	Homo sapiens	P48788	NMR	24333682

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNNC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71372	Troponin C/TNNC1 Protein, Human (His)	P63316 (M1-E161)	≥95%
HY-P71372A	Troponin C/TNNC1 Protein, Human (N-His)	P63316 (M1-E161)	≥95%

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 13

Hypertrophic Cardiomyopathy 13	CMH13
Cardiomyopathy, Hypertrophic, 13	Cardiomyopathy Familial Hypertrophic 13
Cardiomyopathy, Familial Hypertrophic 13	Cardiomyopathy, Hypertrophic, Familial, Type 13

Cardiomyopathy, Dilated, 1z

CMD1Z	Dilated Cardiomyopathy 1z
Cardiomyopathy, Dilated 1z	Cardiomyopathy, Dilated, Type 1z

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9	Left Ventricular Noncompaction 5
Dilated Cardiomyopathy 1e	Dilated Cardiomyopathy 1s
CMD1E	Cdcd2
Cardiomyopathy, Dilated, 1y	CMD1Y
Cardiomyopathy, Dilated, 1s	CMD1S
Dilated Cardiomyopathy 1y	Dilated Cardiomyopathy With Conduction Defect 2
Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia	Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia
Cardiomyopathy, Dilated, With Conduction Defect 2	Cardiomyopathy Dilated With Conduction Defect Type 2
Cardiomyopathy, Dilated 1e	Cardiomyopathy, Dilated 1s
Cardiomyopathy, Dilated 1y	Left Ventricular Non-Compaction 5
LVNC5	Left Ventricular Non-Compaction 9
LVNC9	Cardiomyopathy, Dilated, Type 1e
Cardiomyopathy, Dilated, Type 1s	Cardiomyopathy, Dilated, Type 1y

Cardiomyopathy, Dilated, 1ee

Dilated Cardiomyopathy 1ee	CMD1EE
Cardiomyopathy, Dilated 1ee	Cardiomyopathy, Dilated, Type 1ee

Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy	Cardiomyopathy, Restrictive
Cardiomyopathy, Constrictive	Primary Restrictive Cardiomyopathy
Rcm	Cardiomyopathy Restrictive

Cardiomyopathy, Familial Hypertrophic, 26

Hypertrophic Cardiomyopathy 26	CMH26
Cardiomyopathy, Familial Restrictive 5	Cardiomyopathy, Familial Restrictive, 5
Cardiomyopathy Familial Hypertrophic 26	Cardiomyopathy, Familial Hypertrophic 26
RCM5

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Hemochromatosis, Type 2b

Hemochromatosis Type 2b	HFE2B
Hemochromatosis 2b

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14848	TNNC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TNNC1	VGNC	VGNC:78602
Canis familiaris	TNNC1	VGNC	VGNC:47686
Bos taurus	TNNC1	VGNC	VGNC:36189
Mus musculus	TNNC1	MGD	MGI:98779
Felis catus	TNNC1	VGNC	VGNC:66425
Rattus norvegicus	TNNC1	RGD	RGD:1309921
Others	TNNC1	NCBI

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