TNP1 - transition protein 1 Gene

Homo sapiens

Also known as TP1

Gene ID: 7141 | Gene type: protein coding

About TNP1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:216,859,458-216,860,064 (from NCBI)

This gene has 1 transcript (splice variant) and 83 orthologues. Restricted expression toward testis (RPKM 903.2).

Summary

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]

TNP1 Products(1)

mRNA	Protein	Name
NM_003284.4	NP_003275.1	spermatid nuclear transition protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	12743712	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	12743712	GOA
involved in flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	10781074	GOA
involved in heterochromatin formation	IEP IEP: Inferred from expression pattern	11315969	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12743712	GOA
involved in nucleosome disassembly	IMP IMP: Inferred from mutant phenotype	10781074	GOA
involved in sexual reproduction	IMP IMP: Inferred from mutant phenotype	10781074	GOA
involved in single strand break repair	IDA IDA: Inferred from direct assay	12743712	GOA
involved in spermatid development	IDA IDA: Inferred from direct assay	12743712	GOA
involved in spermatid nucleus elongation	IMP IMP: Inferred from mutant phenotype	10781074	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nucleosome	IDA IDA: Inferred from direct assay	12743712	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNP1 Protein Structure

TP1

0
55 a.a.

Protein Preferred Names

Protein Names

spermatid nuclear transition protein 1

STP-1

Related Diseases

Diseases

Alias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome	Germinal Cell Aplasia
Del Castillo Syndrome	SPGFX1
X-Linked Spermatogenic Failure 1	Congenital Absence Of Germinal Epithelium Of Testes

Infertility

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Oligospermia

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14857	TNP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNP1	RGD	RGD:3884
Macaca mulatta	TNP1	VGNC	VGNC:104561
Bos taurus	TNP1	VGNC	VGNC:36197
Canis familiaris	TNP1	VGNC	VGNC:47693
Felis catus	TNP1	VGNC	VGNC:80389
Mus musculus	TNP1	MGD	MGI:98784

Name
Email *

	Sorry, but the email address you supplied was invalid.