SDCBP2 - syndecan binding protein 2 Gene

Homo sapiens

Also known as ST2; ST-2; SITAC; SITAC18

Gene ID: 27111 | Gene type: protein coding

About SDCBP2

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,309,909-1,329,139 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues and 4 paralogues. Biased expression in duodenum (RPKM 54.3), small intestine (RPKM 53.5) and 8 other tissues.

Summary

The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]

SDCBP2 Products(3)

mRNA	Protein	Name
NM_001199784.2	NP_001186713.1	syntenin-2 isoform a
NM_015685.6	NP_056500.2	syntenin-2 isoform b
NM_080489.5	NP_536737.3	syntenin-2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	15961997	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11102519	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11152476	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11152476	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	15961997	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11152476	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	15961997	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	15961997	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15961997	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDCBP2 Protein Structure

PDZ

0
100
200
292 a.a.

Protein Preferred Names

Protein Names

syntenin-2

syndecan binding protein (syntenin) 2

SDCBP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SDCBP2	Q9H190	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	SDCBP2	Q9H190	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	SDCBP2	Q9H190	rnps1	Homo sapiens	D3DU92	Validated Y2H	25416956
Intra	SDCBP2	Q9H190	rnps1	Homo sapiens	D3DU92	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	NKAPD1	Homo sapiens	Q6ZUT1-2	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	NKAPD1	Homo sapiens	Q6ZUT1-2	Validated Y2H	25416956
Intra	SDCBP2	Q9H190	TNP1	Homo sapiens	P09430	Y2H Array	25416956
Intra	SDCBP2	Q9H190	FAM133A	Homo sapiens	Q8N9E0	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	FAM133A	Homo sapiens	Q8N9E0	BFG-2H	27107012
Intra	SDCBP2	Q9H190	FAM133A	Homo sapiens	Q8N9E0	Y2H Array	25416956
Intra	SDCBP2	Q9H190	FAM133A	Homo sapiens	Q8N9E0	Validated Y2H	27107012
Intra	SDCBP2	Q9H190	SREK1IP1	Homo sapiens	Q8N9Q2	Validated Y2H	25416956
Intra	SDCBP2	Q9H190	LGALS14	Homo sapiens	Q8TCE9	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	LGALS14	Homo sapiens	Q8TCE9	Y2H Array	25416956
Intra	SDCBP2	Q9H190	ARF4	Homo sapiens	P18085	Y2H Array	25416956
Intra	SDCBP2	Q9H190	TCP11L1	Homo sapiens	Q9NUJ3	Validated Y2H	32296183
Intra	SDCBP2	Q9H190	YTHDC1	Homo sapiens	Q96MU7	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	RPL22	Homo sapiens	P35268	Validated Y2H	27107012
Intra	SDCBP2	Q9H190	NKAPD1	Homo sapiens	Q6ZUT1	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	PRPF40A	Homo sapiens	O75400-2	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	PRPF40A	Homo sapiens	O75400-2	Y2H Array	25416956
Intra	SDCBP2	Q9H190	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	ZCCHC10	Homo sapiens	Q8TBK6	Validated Y2H	25416956
Intra	SDCBP2	Q9H190	ZRSR2	Homo sapiens	Q15696	Validated Y2H	25416956
Intra	SDCBP2	Q9H190	NPM2	Homo sapiens	Q86SE8	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	NPM2	Homo sapiens	Q86SE8	Validated Y2H	25416956
Intra	SDCBP2	Q9H190	LYAR	Homo sapiens	Q9NX58	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	LYAR	Homo sapiens	Q9NX58	Y2H Array	31515488
Intra	SDCBP2	Q9H190	LYAR	Homo sapiens	Q9NX58	Validated Y2H	32296183
Intra	SDCBP2	Q9H190	CRCT1	Homo sapiens	Q9UGL9	Validated Y2H	32296183
Intra	SDCBP2	Q9H190	TM4SF1	Homo sapiens	P30408	Y2H	11102519
Intra	SDCBP2	Q9H190	TM4SF1	Homo sapiens	P30408	Confocal	11102519
Intra	SDCBP2	Q9H190	ADAP1	Homo sapiens	O75689	Validated Y2H	25416956
Intra	SDCBP2	Q9H190	ADAP1	Homo sapiens	O75689	Y2H Array	25416956
Intra	SDCBP2	Q9H190	LGALS2	Homo sapiens	P05162	Validated Y2H	25416956
Intra	SDCBP2	Q9H190	NFU1	Homo sapiens	Q9UMS0	Validated Y2H	32296183
Intra	SDCBP2	Q9H190	PHC1	Homo sapiens	P78364	Y2H Array	32296183
Intra	SDCBP2	Q9H190	FBXO28	Homo sapiens	Q9NVF7	Validated Y2H	32296183
Intra	SDCBP2	Q9H190	FBXO28	Homo sapiens	Q9NVF7	Y2H Array	25416956
Intra	SDCBP2	Q9H190	TIFA	Homo sapiens	Q96CG3	Y2H Pooling	16189514
Intra	SDCBP2	Q9H190	TIFA	Homo sapiens	Q96CG3	Validated Y2H	27107012
Intra	SDCBP2	Q9H190	PRR13	Homo sapiens	Q9NZ81	Validated Y2H	32296183
Intra	SDCBP2	Q9H190	PRR13	Homo sapiens	Q9NZ81	Y2H Pooling	16189514
Intra	SDCBP2	Q9H190	PRR13	Homo sapiens	Q9NZ81	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	ZCCHC17	Homo sapiens	Q9NP64	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	ZCCHC17	Homo sapiens	Q9NP64	Validated Y2H	32296183
Intra	SDCBP2	Q9H190	CT45A3	Homo sapiens	Q8NHU0	Y2H Prey Pooling	25416956
Intra	SDCBP2	Q9H190	ZCCHC17	Homo sapiens	Q9NP64	Y2H Pooling	16189514
Intra	SDCBP2	Q9H190	CT45A3	Homo sapiens	Q8NHU0	Y2H Array	25416956
Intra	SDCBP2	Q9H190	ZCCHC17	Homo sapiens	Q9NP64	Validated Y2H	25416956
Intra	SDCBP2	Q9H190	CT45A3	Homo sapiens	Q8NHU0	Y2H	21516116
Intra	SDCBP2	Q9H190	MMTAG2	Homo sapiens	Q9BU76	Y2H Pooling	16189514
Intra	SDCBP2	Q9H190	ZNF581	Homo sapiens	Q9P0T4	Y2H Array	25416956
Intra	SDCBP2	Q9H190	EIF1AD	Homo sapiens	Q8N9N8	Validated Y2H	25416956
Intra	SDCBP2	Q9H190	EIF1AD	Homo sapiens	Q8N9N8	Y2H Array	25416956
Intra	SDCBP2	Q9H190	FAM13C	Homo sapiens	Q8NE31	Y2H Array	25416956
Intra	SDCBP2	Q9H190	CT45A5	Homo sapiens	Q6NSH3	Y2H Array	25416956
Cross	SDCBP2	Q9H190	Tgfa	Rattus norvegicus	P01134	Y2H	11102519

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lissencephaly 9 With Complex Brainstem Malformation

LIS9	Posterior-Predominant Lissencephaly-Broad Flat Pons And Medulla-Midline Crossing Defects Syndrome

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12584	SDCBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SDCBP2	VGNC	VGNC:64947
Macaca mulatta	SDCBP2	VGNC	VGNC:77017
Canis familiaris	SDCBP2	VGNC	VGNC:45945
Mus musculus	SDCBP2	MGD	MGI:2385156
Rattus norvegicus	SDCBP2	RGD	RGD:1307709
Bos taurus	SDCBP2	VGNC	VGNC:34383

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