2. Gene
  3. Ptk7 - PTK7 protein tyrosine kinase 7 Gene

Ptk7 - PTK7 protein tyrosine kinase 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as chz; mPTK7/CCK4; 8430404F20Rik

Gene ID: 71461 | Gene type: protein coding

About Ptk7

Summary

Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within several processes, including animal organ development; axis elongation; and morphogenesis of an epithelium. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; nervous system; paraxial mesenchyme; reproductive system; and sensory organ. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]

Ptk7 Products(1)

mRNA Protein Name
NM_175168.4 NP_780377.1 inactive tyrosine-protein kinase 7 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
NOT enables kinase activity IDA
IDA: Inferred from direct assay
15019986 MGI
NOT enables transmembrane receptor protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
15019986 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within axis elongation IMP
IMP: Inferred from mutant phenotype
20704721 MGI
acts upstream of or within cochlea morphogenesis IMP
IMP: Inferred from mutant phenotype
20704721 MGI
acts upstream of or within convergent extension IMP
IMP: Inferred from mutant phenotype
20704721 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within establishment of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
15229603 MGI
acts upstream of or within establishment of planar polarity IMP
IMP: Inferred from mutant phenotype
20704721 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
27002738 MGI
acts upstream of or within lung-associated mesenchyme development IMP
IMP: Inferred from mutant phenotype
20704721 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
15229603 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
15229603 MGI
NOT acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15019986 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within wound healing IGI
IGI: Inferred from genetic interaction
20643356 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
20215345 MGI
located in membrane IDA
IDA: Inferred from direct assay
20704721 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
20215345 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inactive tyrosine-protein kinase 7

protein chuzhoi

protein-tyrosine kinase 7

pseudo tyrosine kinase receptor 7

receptor tyrosine kinase-like protein

tyrosine-protein kinase-like 7

Recombinant Ptk7 Proteins

Cat. No. Product Name Accession Purity
HY-P78761 PTK7 Protein, Mouse (HEK293, His) Q8BKG3 (A23-T696) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99828 Cofetuzumab Inhibitor 96.53% Phase 1
HY-P99829 Cofetuzumab pelidotin Inhibitor 99.67% Phase 1
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-160493 PTK7/β-catenin-IN-6 Inhibitor / Unkown
HY-160488 PTK7/β-catenin-IN-1 Inhibitor 99.99% Unkown
HY-160489 PTK7/β-catenin-IN-2 Inhibitor 96.96% Unkown
HY-RS11404 PTK7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptk7 NCBI NCBI:5754
Macaca fascicularis Ptk7 NCBI NCBI:102126644
Leporidae Ptk7 NCBI
Rattus norvegicus Ptk7 NCBI NCBI:301242
Macaca mulatta Ptk7 NCBI NCBI:699791