PTK7 - protein tyrosine kinase 7 (inactive) Gene

Homo sapiens

Also known as CCK4; CCK-4

Gene ID: 5754 | Gene type: protein coding

About PTK7

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,076,314-43,161,715 (from NCBI)

This gene has 20 transcripts (splice variants) and 229 orthologues. Broad expression in endometrium (RPKM 43.5), ovary (RPKM 31.2) and 19 other tissues.

Summary

This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PTK7 Products(5)

mRNA	Protein	Name
NM_001270398.2	NP_001257327.1	inactive tyrosine-protein kinase 7 isoform e
NM_002821.5	NP_002812.2	inactive tyrosine-protein kinase 7 isoform a precursor
NM_152880.4	NP_690619.1	inactive tyrosine-protein kinase 7 isoform b precursor
NM_152881.4	NP_690620.1	inactive tyrosine-protein kinase 7 isoform c precursor
NM_152882.4	NP_690621.1	inactive tyrosine-protein kinase 7 isoform d precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21132015	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20837484	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	20837484	GOA
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	21132015	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17910947	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	20837484	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTK7 Protein Structure

I-set

Ig_2

I-set

Pkinase_Tyr

0
200
400
600
800
1000
1070 a.a.

Protein Preferred Names

Protein Names

inactive tyrosine-protein kinase 7

PTK7 protein tyrosine kinase 7

Recombinant PTK7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71821	PTK7 Protein, Human (P.pastoris, His)	Q13308-1 (A31-T704)	≥95%
HY-P78398	PTK7 Protein, Human (HEK293, His)	Q13308-1 (A31-T704)	≥95%

Related Diseases

Diseases

Alias

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Agoraphobia

Fear Of Open Spaces

Phobia Of Going Out

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Scoliosis

Myelomeningocele

Meningomyelocele

Phobic Disorder

Phobic Disorders

Phobic Anxiety Disorder

Syringomyelia

Hydromyelia

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99829	Cofetuzumab pelidotin	Inhibitor	99.67%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160493	PTK7/β-catenin-IN-6	Inhibitor	/	Unkown
HY-160488	PTK7/β-catenin-IN-1	Inhibitor	/	Unkown
HY-160489	PTK7/β-catenin-IN-2	Inhibitor	96.96%	Unkown
HY-RS11404	PTK7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTK7	VGNC	VGNC:54670
Felis catus	PTK7	VGNC	VGNC:102498
Macaca mulatta	PTK7	VGNC	VGNC:83451
Mus musculus	PTK7	MGD	MGI:1918711
Rattus norvegicus	PTK7	RGD	RGD:1310472
Macaca fascicularis	PTK7	NCBI	NCBI:102126644
Leporidae	PTK7	NCBI
Others	PTK7	NCBI

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