TPBG - trophoblast glycoprotein Gene

Homo sapiens

Also known as 5T4; M6P1; 5T4AG; WAIF1

Gene ID: 7162 | Gene type: protein coding

About TPBG

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:82,362,983-82,367,420 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele and 185 orthologues. Ubiquitous expression in esophagus (RPKM 8.0), endometrium (RPKM 5.0) and 22 other tissues.

Summary

This gene encodes a leucine-rich Transmembrane Glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

TPBG Products(3)

mRNA	Protein	Name
NM_001166392.2	NP_001159864.1	trophoblast glycoprotein precursor
NM_001376922.1	NP_001363851.1	trophoblast glycoprotein precursor
NM_006670.5	NP_006661.1	trophoblast glycoprotein precursor

TPBG Protein Structure

LRRNT

LRR_8

LRRCT

0
100
200
300
420 a.a.

Protein Preferred Names

Protein Names

trophoblast glycoprotein

5T4 oncofetal antigen

Recombinant TPBG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70512	TPBG/5T4 Protein, Human (HEK293, His)	Q13641 (S32-S355)	≥95%
HY-P71374	TPBG/5T4 Protein, Human (HEK293, mFc)	Q13641 (S32-S355)	≥95%
HY-P72421	TPBG/5T4 Protein, Human (HEK293, Avi-His)	Q13641 (S32-S355)	≥95%
HY-P78053	TPBG/5T4 Protein, Human (Biotinylated, HEK293, His-Avi)	Q13641 (S32-S355)	≥95%
HY-P700840	TPBG/5T4 Protein, Human (FITC, HEK293, His-Avi)	Q13641-1 (S32-S355)	≥95%
HY-P701049	TPBG/5T4 Protein, Human (HEK293, hFc)	Q13641 (S32-S355)	≥95%

Related Diseases

Diseases

Alias

Congenital Disorder Of Glycosylation, Type Il

Cdg Il	CDG1L
Cdgil	Congenital Disorder Of Glycosylation Il
Congenital Disorder Of Glycosylation 1l	Cdg-Il
Congenital Disorder Of Glycosylation Type Il	Glycosylation, Congenital Disorder Of, Type Il
Congenital Disorder Of Glycosylation Type 1l

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14925	TPBG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TPBG	VGNC	VGNC:47731
Felis catus	TPBG	VGNC	VGNC:66469
Rattus norvegicus	TPBG	RGD	RGD:621453
Bos taurus	TPBG	VGNC	VGNC:36242
Mus musculus	TPBG	MGD	MGI:1341264
Macaca mulatta	TPBG	VGNC	VGNC:78631
Macaca fascicularis	TPBG	NCBI	NCBI:102132149
Others	TPBG	NCBI

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