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  3. TPBG/5T4 Protein, Human (HEK293, mFc)

TPBG/5T4 protein acts as an inhibitor of Wnt/β-catenin signaling, possibly by interacting indirectly with LRP6 and hindering Wnt3a-dependent LRP6 internalization. This means that TPBG/5T4 plays a crucial role in regulating the complex Wnt/β-catenin signaling pathway and exerts a regulatory influence on cellular responses related to this pathway. TPBG/5T4 Protein, Human (HEK293, mFc) is the recombinant human-derived TPBG/5T4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TPBG/5T4 Protein, Human (HEK293, mFc) is 324 a.a., with molecular weight of 80-110 kDa.

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Description

TPBG/5T4 protein acts as an inhibitor of Wnt/β-catenin signaling, possibly by interacting indirectly with LRP6 and hindering Wnt3a-dependent LRP6 internalization. This means that TPBG/5T4 plays a crucial role in regulating the complex Wnt/β-catenin signaling pathway and exerts a regulatory influence on cellular responses related to this pathway. TPBG/5T4 Protein, Human (HEK293, mFc) is the recombinant human-derived TPBG/5T4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TPBG/5T4 Protein, Human (HEK293, mFc) is 324 a.a., with molecular weight of 80-110 kDa.

Background

The TPBG/5T4 protein appears to serve as an inhibitor of Wnt/beta-catenin signaling, potentially achieved through indirect interaction with LRP6, thereby impeding Wnt3a-dependent LRP6 internalization. This implies a crucial role for TPBG/5T4 in modulating the intricate Wnt/beta-catenin signaling pathway, exerting regulatory influence on cellular responses associated with this pathway. Further exploration of the specific molecular mechanisms governing the interaction between TPBG/5T4 and LRP6, as well as its impact on Wnt3a-dependent LRP6 internalization, could yield valuable insights into the functional significance of TPBG/5T4 in shaping Wnt/beta-catenin signaling dynamics and its potential implications for various cellular processes.

Species

Human

Source

HEK293

Tag

C-mFc

Accession

Q13641 (S32-S355)

Gene ID
Molecular Construction
N-term
TLR8 (S32-S355)
Accession # Q13641
mFc
C-term
Synonyms
TPBG; 5T4 ; 5T4AG; M6P1; WAIF1
AA Sequence

SSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTS

Molecular Weight

80-110 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

TPBG/5T4 Protein, Human (HEK293, mFc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
TPBG/5T4 Protein, Human (HEK293, mFc)
Cat. No.:
HY-P71374
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