TPD52L2 - TPD52 like 2 Gene

Homo sapiens

Also known as D54; TPD54

Gene ID: 7165 | Gene type: protein coding

About TPD52L2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,865,270-63,891,538 (from NCBI)

This gene has 10 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 35.6), bone marrow (RPKM 34.4) and 25 other tissues.

Summary

This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast Cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]

TPD52L2 Products(10)

mRNA	Protein	Name
NM_001243891.2	NP_001230820.1	tumor protein D54 isoform g
NM_001243892.2	NP_001230821.1	tumor protein D54 isoform h
NM_001243894.2	NP_001230823.1	tumor protein D54 isoform i
NM_001243895.2	NP_001230824.1	tumor protein D54 isoform j
NM_003288.4	NP_003279.2	tumor protein D54 isoform e
NM_199359.3	NP_955391.1	tumor protein D54 isoform f
NM_199360.3	NP_955392.1	tumor protein D54 isoform a
NM_199361.3	NP_955393.1	tumor protein D54 isoform b
NM_199362.3	NP_955394.1	tumor protein D54 isoform c
NM_199363.3	NP_955395.1	tumor protein D54 isoform d

TPD52L2 Protein Structure

TPD52

0
100
206 a.a.

Protein Preferred Names

Protein Names

tumor protein D54

HCCR-binding protein 2

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14930	TPD52L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TPD52L2	VGNC	VGNC:47735
Rattus norvegicus	TPD52L2	RGD	RGD:735167
Bos taurus	TPD52L2	VGNC	VGNC:36246
Macaca mulatta	TPD52L2	VGNC	VGNC:98462
Mus musculus	TPD52L2	MGD	MGI:1913564
Felis catus	TPD52L2	VGNC	VGNC:66472

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