Cic - capicua transcriptional repressor Gene

Mus musculus

Also known as mKIAA0306; 1200010B10Rik

Gene ID: 71722 | Gene type: protein coding

About Cic

Summary

Enables chromatin binding activity. Involved in several processes, including learning or memory; negative regulation of transcription, DNA-templated; and social behavior. Acts upstream of or within lung alveolus development and negative regulation of transcription by RNA polymerase II. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Used to study disease of mental health. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 45. Orthologous to human CIC (capicua transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]

Cic Products(2)

mRNA	Protein	Name
NM_001302811.1	NP_001289740.1	protein capicua homolog isoform CIC-L
NM_027882.4	NP_082158.2	protein capicua homolog isoform CIC-S

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	20628574	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18337722	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in brain development	IMP IMP: Inferred from mutant phenotype	28288114	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	28288114	MGI
acts upstream of or within lung alveolus development	IGI IGI: Inferred from genetic interaction	22014525	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	22014525	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	28288114	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	28288114	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20628574	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	28288114	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22014525	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	18337722	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein capicua homolog

capicua homolog

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0679	Lubiprostone		≥98.0%	Yes
HY-15790A	Elobixibat hydrate		99.44%	Unkown

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15888	PTC-209		99.76%	Unkown
HY-111490	Desisobutyryl-ciclesonide	Modulator	99.53%	Unkown
HY-15888A	PTC-209 hydrobromide		99.44%	Unkown
HY-16905	T338C Src-IN-1	Inhibitor	/	Unkown
HY-111490R	Desisobutyryl-ciclesonide (Standard)	Modulator	/	Unkown
HY-125551	L-687908	Inhibitor	/	Unkown
HY-164532	NS3736	Inhibitor	/	Unkown
HY-RS02710	CIC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cic	NCBI	NCBI:23152
Macaca fascicularis	Cic	NCBI	NCBI:102146273

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