Tmem106b - transmembrane protein 106B Gene

Mus musculus

Also known as 2310036D22Rik; 5830455K21Rik; 6430519M21Rik

Gene ID: 71900 | Gene type: protein coding

About Tmem106b

Summary

Enables ATPase binding activity. Acts upstream of or within several processes, including lysosomal lumen acidification; lysosomal protein catabolic process; and positive regulation of dendrite development. Located in lysosome. Is expressed in several structures, including alimentary system; hemolymphoid system gland; integumental system; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human TMEM106B (transmembrane protein 106B). [provided by Alliance of Genome Resources, Apr 2022]

Tmem106b Products(1)

mRNA	Protein	Name
NM_027992.3	NP_082268.2	transmembrane protein 106B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	28728022	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within lysosomal lumen acidification	IMP IMP: Inferred from mutant phenotype	28728022	MGI
acts upstream of or within lysosomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	28728022	MGI
acts upstream of or within lysosomal transport	IMP IMP: Inferred from mutant phenotype	25066864	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	25066864	MGI
acts upstream of or within neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	28728022	MGI
acts upstream of or within positive regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	25066864	MGI
acts upstream of or within positive regulation of hydrolase activity	IMP IMP: Inferred from mutant phenotype	28728022	MGI
acts upstream of or within regulation of lysosome organization	IMP IMP: Inferred from mutant phenotype	28728022	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in lysosome	IDA IDA: Inferred from direct assay	25066864	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transmembrane protein 106B

Recombinant Tmem106b Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77854	TMEM106B Protein, Mouse (HEK293, Fc)	Q80X71 (P119-Q275)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14646	TMEM106B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tmem106b	NCBI	NCBI:54664

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