C4BPA - complement component 4 binding protein alpha Gene

Homo sapiens

Also known as PRP; C4BP

Gene ID: 722 | Gene type: protein coding

About C4BPA

Cytogenetic location: 1q32.2 Genomic coordinates (GRCh38): 1:207,104,233-207,144,972 (from NCBI)

This gene has 3 transcripts (splice variants), 146 orthologues and 39 paralogues. Biased expression in liver (RPKM 372.5) and lung (RPKM 75.1).

Summary

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 Amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]

C4BPA Products(1)

mRNA	Protein	Name
NM_000715.4	NP_000706.1	C4b-binding protein alpha chain precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14607961	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of complement activation, classical pathway	IDA IDA: Inferred from direct assay	22333221	GOA
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	22333221	GOA
involved in regulation of opsonization	IDA IDA: Inferred from direct assay	22333221	GOA
involved in response to symbiotic bacterium	IDA IDA: Inferred from direct assay	22333221	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	14607961	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C4BPA Protein Structure

Sushi

0
100
200
300
400
500
597 a.a.

Protein Preferred Names

Protein Names

C4b-binding protein alpha chain

proline-rich protein

Related Diseases

Diseases

Alias

Protein S Deficiency

Protein S Deficiency Disease

Hereditary Thrombophilia Due To Protein S Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01747	C4BPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	C4BPA	RGD	RGD:2235
Bos taurus	C4BPA	VGNC	VGNC:103055
Macaca mulatta	C4BPA	VGNC	VGNC:70474
Canis familiaris	C4BPA	VGNC	VGNC:38593

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