Sting1 - stimulator of interferon response cGAMP interactor 1 Gene

Mus musculus

Also known as ERIS; MPYS; Mita; STING; Tmem173; STING-beta; 2610307O08Rik

Gene ID: 72512 | Gene type: protein coding

About Sting1

Chromosome 18: 35,866,732-35,873,607 reverse strand.GRCm39:CM001011.3

This gene has 10 transcripts (splice variants), 184 orthologues and is associated with 35 phenotypes. Broad expression in spleen adult (RPKM 3.3), mammary gland adult (RPKM 29.1) and 2 other tissues.

Summary

Enables 2',3'-cyclic GMP-AMP binding activity; cyclic-di-GMP binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including defense response to Other organism; macroautophagy; and positive regulation of interferon-beta production. Acts upstream of or within cellular response to interferon-beta; positive regulation of transcription by RNA polymerase II; and regulation of inflammatory response. Located in several cellular components, including autophagosome; perinuclear region of cytoplasm; and peroxisome. Is expressed in ductus deferens; epididymis; ileum; and prostate gland. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sting1 Products(3)

mRNA	Protein	Name
NM_028261.1	NP_082537.1	stimulator of interferon genes protein isoform 1
NM_001289592.1	NP_001276521.1	stimulator of interferon genes protein isoform 3
NM_001289591.1	NP_001276520.1	stimulator of interferon genes protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2',3'-cyclic GMP-AMP binding	IDA IDA: Inferred from direct assay	23258412	MGI
enables cyclic-di-GMP binding	IDA IDA: Inferred from direct assay	21947006	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21892174	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	21074459	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	23910378	MGI
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	21947006	MGI
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	30568238	MGI
involved in cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	37832545	MGI
acts upstream of or within cellular response to interferon-beta	IMP IMP: Inferred from mutant phenotype	21892174	MGI
involved in cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	26669264	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	21892174	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	19776740	MGI
involved in innate immune response	IDA IDA: Inferred from direct assay	23910378	MGI
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	19433799	MGI
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	19433799	MGI
involved in positive regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	30568238	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21892174	MGI
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	26669264	MGI
involved in positive regulation of type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	23910378	MGI
acts upstream of or within regulation of cellular metabolic process	IGI IGI: Inferred from genetic interaction	28069950	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	23160154	MGI
acts upstream of or within regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	28069950	MGI
involved in reticulophagy	IDA IDA: Inferred from direct assay	29056340	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19926846	MGI
located in Golgi membrane	IDA IDA: Inferred from direct assay	27324217	MGI
part of STING complex	IPI IPI: Inferred from physical interaction	23910378	MGI
located in autophagosome	IDA IDA: Inferred from direct assay	29056340	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	24560620	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19926846	MGI
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	37832545	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	19776740	MGI
is active in endoplasmic reticulum-Golgi intermediate compartment membrane	IDA IDA: Inferred from direct assay	37832545	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19776740	MGI
located in peroxisome	IDA IDA: Inferred from direct assay	22745163	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sting1 Protein Structure

TMEM173

0
100
200
300
378 a.a.

Protein Preferred Names

Protein Names

stimulator of interferon genes protein

endoplasmic reticulum interferon stimulator	mediator of IRF3 activation
mitochondrial mediator of IRF3 activation	stimulator of interferon protein
transmembrane protein 173

Sting1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sting1	Q3TBT3	Ddx41	Mus musculus	Q91VN6	Anti Bait CoIP	23142775
Intra	Sting1	Q3TBT3	Ddx41	Mus musculus	Q91VN6	Confocal	23142775
Intra	Sting1	Q3TBT3	Igf2r	Mus musculus	Q07113	Anti Bait CoIP	37863414
Intra	Sting1	Q3TBT3	Tbk1	Mus musculus	Q9WUN2	Anti Bait CoIP	22000020
Intra	Sting1	Q3TBT3	Tbk1	Mus musculus	Q9WUN2	Anti Bait CoIP	23142775

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112906	C-176	Inhibitor	99.45%	Unkown
HY-138683	STING-IN-3	Inhibitor	99.86%	Unkown
HY-114399	STING ligand-1		99.79%	Unkown
HY-12885C	2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt		98.82%	Unkown
HY-RS13917	Sting1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13916	STING1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13918	Sting1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-163643	STING modulator-7	Modulator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sting1	NCBI	NCBI:340061

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