Tbk1 - TANK-binding kinase 1 Gene

Mus musculus

Also known as 1200008B05Rik

Gene ID: 56480 | Gene type: protein coding

About Tbk1

Chromosome 10: 121,382,360-121,422,692 reverse strand.GRCm39:CM001003.3

This gene has 7 transcripts (splice variants), 201 orthologues, 3 paralogues and is associated with 38 phenotypes. Ubiquitous expression in bladder adult (RPKM 7.5), CNS E11.5 (RPKM 7.4) and 28 other tissues.

Summary

Enables several functions, including identical protein binding activity; protein Phosphatase binding activity; and protein serine/threonine kinase activity. Involved in negative regulation of gene expression; peptidyl-serine phosphorylation; and positive regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Tbk1 Products(1)

mRNA	Protein	Name
NM_019786.4	NP_062760.3	serine/threonine-protein kinase TBK1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22728658	MGI
enables nucleic acid binding	IDA IDA: Inferred from direct assay	19158679	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10581243	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	17954568	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	21617041	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within activation of innate immune response	IMP IMP: Inferred from mutant phenotype	15661922	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	15661922	MGI
acts upstream of or within dendritic cell proliferation	IGI IGI: Inferred from genetic interaction	23610142	MGI
acts upstream of interferon-beta production	IMP IMP: Inferred from mutant phenotype	15661922	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18665841	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	21617041	MGI
acts upstream of or within positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	15661922	MGI
involved in positive regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	27129230	MGI
involved in positive regulation of xenophagy	IMP IMP: Inferred from mutant phenotype	21617041	MGI
acts upstream of or within regulation of cellular metabolic process	IGI IGI: Inferred from genetic interaction	28069950	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	23160154	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tbk1 Protein Structure

STKc_TBK1

Ubl_TBK1

TBK1_CCD1

TBK1_C

0
200
400
600
729 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase TBK1

T2K

Tbk1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tbk1	Q9WUN2	Ticam1	Mus musculus	Q80UF7	Anti Bait CoIP	21441935
Intra	Tbk1	Q9WUN2	Tank	Mus musculus	P70347	TAP	18583960
Intra	Tbk1	Q9WUN2	Tank	Mus musculus	P70347	Anti Tag CoIP	10581243
Intra	Tbk1	Q9WUN2	Tank	Mus musculus	P70347	Pull Down	23746807
Intra	Tbk1	Q9WUN2	Tbk1	Mus musculus	Q9WUN2	X-Ray Diffraction	23746807
Intra	Tbk1	Q9WUN2	IRF3	Homo sapiens	Q14653	Protein Kinase Assay	23746807
Intra	Tbk1	Q9WUN2	Tbk1	Mus musculus	Q9WUN2	GMS	23746807
Intra	Tbk1	Q9WUN2	Tbk1	Mus musculus	Q9WUN2	Protein Kinase Assay	23746807
Intra	Tbk1	Q9WUN2	Tbkbp1	Mus musculus	A2A9T0	TAP	18583960
Intra	Tbk1	Q9WUN2	Traf2	Mus musculus	P39429	Anti Tag CoIP	10581243
Intra	Tbk1	Q9WUN2	Sting1	Mus musculus	Q3TBT3-1	Protein Kinase Assay	22728658

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0713	Amlexanox	Inhibitor	99.74%	Unkown

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10514	BX795	Inhibitor	99.84%	Unkown
HY-111941	GSK8612	Inhibitor	99.62%	Unkown
HY-13018	MRT67307	Inhibitor	99.44%	Unkown
HY-133117	BAY-985	Inhibitor	99.88%	Unkown
HY-152237	TBK1-IN-1	Inhibitor	99.91%	Unkown
HY-12453	TBK1/IKKε-IN-2	Inhibitor	98.09%	Unkown
HY-124652	TBK1/IKKε-IN-4	Inhibitor	99.42%	Unkown
HY-14682	GSK319347A	Inhibitor	99.25%	Unkown
HY-13018A	MRT67307 hydrochloride	Inhibitor	/	Unkown
HY-133117A	(Rac)-BAY-985	Inhibitor	/	Unkown
HY-U00457	TBK1/IKKε-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbk1	NCBI	NCBI:29110

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