MUC5B - mucin 5B, oligomeric mucus/gel-forming Gene

Homo sapiens

Also known as MG1; MUC5; MUC9; MUC-5B

Gene ID: 727897 | Gene type: protein coding

About MUC5B

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,223,066-1,262,172 (from NCBI)

This gene has 5 transcripts (splice variants), 151 orthologues, 19 paralogues and is associated with 3 phenotypes. Biased expression in gall bladder (RPKM 56.3), colon (RPKM 19.6) and 3 other tissues.

Summary

This gene encodes a member of the Mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming Mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]

MUC5B Products(1)

mRNA	Protein	Name
NM_002458.3	NP_002449.2	mucin-5B precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	1718282	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MUC5B Protein Structure

VWD

TIL

VWD

TIL

VWD

Mucin2_WxxW

VWD

VWC

0
900
1800
2700
3600
4500
5400
5762 a.a.

Protein Preferred Names

Protein Names

mucin-5B

cervical mucin MUC5B

Related Diseases

Diseases

Alias

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

Idiopathic Interstitial Pneumonia

Hamman-Rich Syndrome	Diffuse Idiopathic Pulmonary Fibrosis
Idiopathic Fibrosing Alveolitis	Ipf
Idiopathic Interstitial Pneumonias	Idiopathic Interstitial Pneumonia, Not Otherwise Specified
Pulmonary Fibrosis

Panbronchiolitis, Diffuse

Diffuse Panbronchiolitis	Dpb
Pblt

Interstitial Lung Disease

Ild	Lung Diseases, Interstitial
Lung Diseases Interstitial	Interstitial Lung Diseases

Pulmonary Fibrosis

Fibrosis Of Lung

Pneumonia

Acute Pneumonia	Pneumonias
Infectious Pneumonia	Pn - [Pneumonia]
Lobar Pneumonia Nos	Multifocal Pneumonia
Orthostatic Pneumonia	Pneumonia Nos
Chronic Pneumonia Nos	Atypical Pneumonia
Passive Pneumonia	Purulent Pneumonia
Interstitial Lobar Pneumonia	Pneumonia, Unspecified
Pneumonia Due To Chlamydia	Pneumonia Due To Chlamydia Pneumoniae
Pneumonia Due To E. Coli	Escherichia Coli Lobar Pneumonia
Pneumonia Due To H. Influenzae	Pneumonia Due To Hemophilus Influenzae
Bronchopneumonia Due To H. Influenzae	Haemophilus Influenzae Lobar Pneumonia
Bronchopneumonia Due To Hemophilus Influenzae	Pseudomonal Pneumonia
Pseudomonas Pneumonia	Pseudomonas Lobar Pneumonia
Staphylococcal Pneumonia	Staphylococcus Pneumonia
Acute Staphylococcal Pneumonia	Staphylococcal Double Pneumonia
Staphylococcal Lobar Pneumonia	Staphylococcal Purulent Pneumonia
Staphylococcal Bronchopneumonia	Pneumococcal Pneumonia
Pneumococcus Pneumonia	Bronchopneumonia Due To S. Pneumoniae
Pneumococcal Lobar Pneumonia	Streptococcal Pneumoniae Pneumonia
Streptococcus Pneumoniae Lobar Pneumonia	Pyemic Pneumococcal Embolism With Pneumonia
Bronchopneumonia Due To Streptococcus Pneumoniae	Pneumonia Due To Streptococcus, Group B
Group B Streptococcal Pneumonia	Adenovirus Pneumonia
Adenoviral Pneumonia	Adenovirus Viral Pneumonia
Pneumonia Respiratory Syncytial Viral	Parainfluenza Viral Pneumonia
Parainfluenzal Pneumonia	Parainfluenza Virus Pneumonia
Human Metapneumovirus Pneumonia	Human Metapneumovirus Infection Resulting In Pneumonia
Pneumocystis Pneumonia	Plasma Cells Pneumonia

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Asbestosis

Idiopathic Interstitial Pneumonitis - From Asbestos Exposure

Pulmonary Fibrosis - From Asbestos Exposure

Bile Duct Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of The Bile Duct

Extrahepatic Bile Duct Mucoepidermoid Carcinoma

Colloid Carcinoma Of The Pancreas

Otitis Media

Opsoclonus-Myoclonus Syndrome	OMS
Otitis Media, Susceptibility To	Kinsbourne Syndrome
Otitis Media, Chronic/Recurrent	Come/Rom
Ataxo-Opso-Myoclonus Syndrome	Dancing Eye Syndrome
Dancing Eye-Dancing Feet Syndrome	Oma Syndrome
Opsoclonus Myoclonus Syndrome	Opsoclonus-Myoclonus-Ataxia Syndrome
Poma Syndrome	Paraneoplastic Opsoclonus-Myoclonus
Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome	Opsoclonus Myoclonus
OM	{Otitis Media, Susceptibility To}
Infectious Otitis Media

Nonspecific Interstitial Pneumonia

Nsip	Non-Specific Interstitial Pneumonia
Non-Specific Idiopathic Interstitial Pneumonia	Non-Specific Interstitial Pneumonia Nos

Intrahepatic Biliary Papillomatosis

Intrahepatic Bile Duct Papillary Neoplasm

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Chronic Ethmoiditis

Chronic Ethmoidal Sinusitis	Chronic Ethmoid Sinusitis
Ethmoidal Sinusitis - Chronic

Lung Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Lung

Bile Duct Mucinous Adenocarcinoma

Mucinous Carcinoma Of The Bile Duct

Extrahepatic Bile Duct Mucinous Adenocarcinoma

Anthracosis

Black Lung	Coal Workers' Pneumoconiosis
Melanoedema	Black Lung Disease
Pneumoconiosis	Coal Miner'S Pneumoconiosis
Coal Workers' Lung	Coal Worker'S Pneumoconiosis
Coal Workers Pneumoconiosis	Coal Miners' Lung
Coal Miners' Pneumoconiosis	Coal Pneumoconiosis
Colliers' Anthracosis	Colliers' Lung
Lung Melanosis	Miners' Asthma
Miners' Lung	Pneumomelanosis
Cwp - [Coalworkers Pneumoconiosis]	Fibrosis Of Lung With Anthracosilicosis
Lung Fibrosis With Anthracosis	Miners' Pneumoconiosis
Carbon Lung	Coalworker Lung
Collier'S Asthma	Anthracosilicosis
Lung Anthracosis

Biliary Papillomatosis

Bile Duct Papillomatosis

Rheumatoid Arthritis Interstitial Lung Disease

Rheumatoid Lung

Interstitial Pneumonitis, Desquamative, Familial

Desquamative Interstitial Pneumonia	DIP
Pneumonitis, Desquamative Interstitial, Familial	Pneumonia, Desquamative Interstitial, Familial
Interstitial Lung Disease, Desquamative	Ild, Desquamative
Familial Desquamative Interstitial Pneumonitis	Rbild
Respiratory Bronchiolitis-Associated Interstitial Lung Disease	Respiratory Bronchiolitis Associated Interstitial Lung Disease

Chronic Purulent Otitis Media

Chronic Suppurative Otitis Media

Csom - [Chronic Suppurative Otitis Media]

Suppurative Otitis Media

Otitis Media With Effusion - Purulent	Purulent Otitis Media
Otitis Media, Suppurative

Middle Ear Disease

Middle Ear Anomaly

Disorder Of Middle Ear

Bile Duct Cystadenocarcinoma

Biliary Cystadenocarcinoma	Intrahepatic Bile Duct Cystadenocarcinoma
Intrahepatic Bile Duct Mucinous Cystic Neoplasm With An Associated Invasive Carcinoma

Bird Fancier'S Lung

Bird Fancier Lung	Pigeon Breeder'S Lung
Avian Hypersensitivity Pneumonitis	Bird Breeder'S Lung
Bird-Fancier'S Lung	Bird-Fanciers' Lung
Poultry Worker'S Lung	Pigeon-Breeder Lung Disease
Pigeon Breeders Lung	Avian Protein Hypersensitivity
Bird Breeders' Disease	Bird Breeders' Lung
Bird Fanciers' Lung	Bird Fanciers' Disease
Bfl - [Bird Fancier Lung]	Fanciers' Disease
Fanciers' Lung

Lymphoid Interstitial Pneumonia

Lymphocytic Interstitial Pneumonia	Lip Disease
Lip Diseases	LIP
Disease Of Lips

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Acute Interstitial Pneumonia

Acute Interstitial Pneumonitis	Hamman-Rich Syndrome
Accelerated Interstitial Pneumonia	Aip
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis, Acute Fatal Form
Idiopathic Pulmonary Fibrosis

Enamel Erosion

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Acute Asthma

Complement Component 7 Deficiency

C7 Deficiency

C7D

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08845	MUC5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MUC5B	MGD	MGI:1921430
Rattus norvegicus	MUC5B	RGD	RGD:1561983
Macaca mulatta	MUC5B	VGNC	VGNC:75081
Canis familiaris	MUC5B	VGNC	VGNC:49928