TXNRD1 - thioredoxin reductase 1 Gene

Homo sapiens

Also known as TR; TR1; TXNR; TRXR1; GRIM-12

Gene ID: 7296 | Gene type: protein coding

About TXNRD1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:104,215,779-104,350,307 (from NCBI)

This gene has 19 transcripts (splice variants), 150 orthologues and 7 paralogues. Ubiquitous expression in adrenal (RPKM 41.8), gall bladder (RPKM 31.2) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]

TXNRD1 Products(7)

mRNA	Protein	Name
NM_001093771.3	NP_001087240.1	thioredoxin reductase 1, cytoplasmic isoform 5
NM_001261445.2	NP_001248374.1	thioredoxin reductase 1, cytoplasmic isoform 3
NM_001261446.2	NP_001248375.1	thioredoxin reductase 1, cytoplasmic isoform 4
NM_003330.4	NP_003321.3	thioredoxin reductase 1, cytoplasmic isoform 2
NM_182729.3	NP_877393.1	thioredoxin reductase 1, cytoplasmic isoform 1
NM_182742.3	NP_877419.1	thioredoxin reductase 1, cytoplasmic isoform 1
NM_182743.3	NP_877420.1	thioredoxin reductase 1, cytoplasmic isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables FAD binding	IDA IDA: Inferred from direct assay	8577704	GOA
enables NADPH peroxidase activity	IDA IDA: Inferred from direct assay	10849437	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	8577704	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15199063	GOA
enables thioredoxin-disulfide reductase (NADPH) activity	IDA IDA: Inferred from direct assay	8577704	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TXNRD1 Protein Structure

Glutaredoxin

Pyr_redox_2

Pyr_redox

Pyr_redox_dim

0
100
200
300
400
500
600
649 a.a.

Protein Preferred Names

Protein Names

thioredoxin reductase 1, cytoplasmic

KM-102-derived reductase-like factor

Recombinant TXNRD1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77258	TRXR1/TXNRD1 Protein, Human (His)	Q16881 (Y161-C647)	≥95%
HY-P77258A	TRXR1/TXNRD1 Protein, Human (N-His)	Q16881 (Y161-C647)	≥95%

Related Diseases

Diseases

Alias

Diphtheria

Corynebacterium Infections	Corynebacterium Infection
Diphtherial Infection	Infection Due To Corynebacterium Diphtheriae

Keshan Disease

Caused By Deficiency Of Selenium In The Diet

Enlarged Heart And Poor Heart Function

Pontocerebellar Hypoplasia, Type 2d

Pontocerebellar Hypoplasia Type 2d	Pcca
PCH2D	Progressive Cerebello-Cerebral Atrophy
Cerebellocerebral Atrophy, Progressive	Pontocerebellar Hypoplasia 2d
Progressive Cerebellocerebral Atrophy	Hypoplasia, Pontocerebellar, Type 2d

Asbestos-Related Lung Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125006	TRi-1	Inhibitor	99.91%	Unkown
HY-147328	LCS3	Inducer	98.65%	Unkown
HY-RS15298	TXNRD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TXNRD1	RGD	RGD:61959
Felis catus	TXNRD1	VGNC	VGNC:66733
Macaca mulatta	TXNRD1	VGNC	VGNC:78679
Canis familiaris	TXNRD1	VGNC	VGNC:48021
Mus musculus	TXNRD1	MGD	MGI:1354175
Bos taurus	TXNRD1	VGNC	VGNC:36545
Others	TXNRD1	NCBI

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