UBE2V1 - ubiquitin conjugating enzyme E2 V1 Gene

Homo sapiens

Also known as CIR1; UEV1; CROC1; UBE2V; UEV-1; UEV1A; CROC-1

Gene ID: 7335 | Gene type: protein coding

About UBE2V1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:50,081,124-50,115,957 (from NCBI)

This gene has 23 transcripts (splice variants), 118 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 23.0), placenta (RPKM 20.8) and 25 other tissues.

Summary

Ubiquitin-conjugating E2 Enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to Other ubiquitin-conjugating Enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]

UBE2V1 Products(17)

mRNA	Protein	Name
NM_001032288.3	NP_001027459.1	ubiquitin-conjugating enzyme E2 variant 1 isoform d
NM_001257393.2	NP_001244322.1	ubiquitin-conjugating enzyme E2 variant 1 isoform a
NM_001257394.2	NP_001244323.1	ubiquitin-conjugating enzyme E2 variant 1 isoform c
NM_001257395.2	NP_001244324.1	ubiquitin-conjugating enzyme E2 variant 1 isoform e
NM_001257396.2	NP_001244325.1	ubiquitin-conjugating enzyme E2 variant 1 isoform f
NM_001257397.2	NP_001244326.1	ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001257398.2	NP_001244327.1	ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001257399.2	NP_001244328.1	ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001282575.3	NP_001269504.1	ubiquitin-conjugating enzyme E2 variant 1 isoform h
NM_001282576.2	NP_001269505.1	ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001282577.3	NP_001269506.1	ubiquitin-conjugating enzyme E2 variant 1 isoform h
NM_001282578.3	NP_001269507.1	ubiquitin-conjugating enzyme E2 variant 1 isoform h
NM_001282579.2	NP_001269508.1	ubiquitin-conjugating enzyme E2 variant 1 isoform g
NM_001282580.2	NP_001269509.1	ubiquitin-conjugating enzyme E2 variant 1 isoform i
NM_021988.6	NP_068823.2	ubiquitin-conjugating enzyme E2 variant 1 isoform a
NM_022442.6	NP_071887.1	ubiquitin-conjugating enzyme E2 variant 1 isoform c
NM_199144.3	NP_954595.1	ubiquitin-conjugating enzyme E2 variant 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16129784	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	16129784	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	16129784	GOA
involved in positive regulation of intracellular signal transduction	IDA IDA: Inferred from direct assay	11057907	GOA
involved in positive regulation of protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	11057907	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	16307917	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of UBC13-MMS2 complex	IDA IDA: Inferred from direct assay	16307917	GOA
part of UBC13-MMS2 complex	IPI IPI: Inferred from physical interaction	11057907	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16129784	GOA
located in cytosol	IDA IDA: Inferred from direct assay	16129784	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22797923	GOA
part of ubiquitin conjugating enzyme complex	IDA IDA: Inferred from direct assay	16129784	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16307917	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2V1 Protein Structure

UQ_con

0
100
147 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 variant 1

DNA-binding protein

Recombinant UBE2V1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71410	UBE2V1 Protein, Human (His)	Q13404 (A2-N147)	≥95%

Related Diseases

Diseases

Alias

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Lidocaine Allergy

Lidoderm Allergy	Lignocaine Allergy
Xylocaine Allergy

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15364	UBE2V1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBE2V1	MGD	MGI:1913839
Canis familiaris	UBE2V1	VGNC	VGNC:54739
Bos taurus	UBE2V1	VGNC	VGNC:106432
Rattus norvegicus	UBE2V1	RGD	RGD:1305503
Others	UBE2V1	NCBI

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