UPP1 - uridine phosphorylase 1 Gene

Homo sapiens

Also known as UP; UPP; UPASE; UDRPASE

Gene ID: 7378 | Gene type: protein coding

About UPP1

Cytogenetic location: 7p12.3 Genomic coordinates (GRCh38): 7:48,088,704-48,108,736 (from NCBI)

This gene has 12 transcripts (splice variants), 229 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 27.1), esophagus (RPKM 7.4) and 19 other tissues.

Summary

This gene encodes a uridine phosphorylase, an Enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded Enzyme functions in the degradation and salvage of pyrimidine ribonucleosides. [provided by RefSeq, Oct 2016]

UPP1 Products(6)

mRNA	Protein	Name
NM_001287426.2	NP_001274355.1	uridine phosphorylase 1 isoform a
NM_001287428.2	NP_001274357.1	uridine phosphorylase 1 isoform b
NM_001287429.2	NP_001274358.1	uridine phosphorylase 1 isoform b
NM_001287430.1	NP_001274359.1	uridine phosphorylase 1 isoform b
NM_001362774.2	NP_001349703.1	uridine phosphorylase 1 isoform a
NM_003364.4	NP_003355.1	uridine phosphorylase 1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19291308	GOA
enables uridine phosphorylase activity	IDA IDA: Inferred from direct assay	7488099	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in uridine catabolic process	IDA IDA: Inferred from direct assay	7488099	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UPP1 Protein Structure

PNP_UDP_1

0
100
200
310 a.a.

Protein Preferred Names

Protein Names

uridine phosphorylase 1

UPase 1

Recombinant UPP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71416	UPP1 Protein, Human (His)	Q86Y75 (M1-A173)	≥95%

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15490	UPP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UPP1	VGNC	VGNC:36688
Felis catus	UPP1	VGNC	VGNC:66846
Mus musculus	UPP1	MGD	MGI:1097668
Rattus norvegicus	UPP1	RGD	RGD:1305566
Macaca mulatta	UPP1	VGNC	VGNC:78726
Others	UPP1	NCBI

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