VGF - VGF nerve growth factor inducible Gene

Homo sapiens

Also known as SCG7; SgVII

Gene ID: 7425 | Gene type: protein coding

About VGF

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,162,509-101,169,952 (from NCBI)

This gene has 2 transcripts (splice variants) and 72 orthologues. Biased expression in brain (RPKM 14.2) and fat (RPKM 1.5).

Summary

This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

VGF Products(1)

mRNA	Protein	Name
NM_003378.4	NP_003369.2	neurosecretory protein VGF precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to cAMP	IEP IEP: Inferred from expression pattern	10381005	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	17440014	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	15706611	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurosecretory protein VGF

neuro-endocrine specific protein VGF

Related Diseases

Diseases

Alias

Vaccinia

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Spinocerebellar Ataxia 23

Spinocerebellar Ataxia Type 23	SCA23
Ataxia, Spinocerebellar, Type 23

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1345A	TLQP-21 TFA	Agonist	99.90%	Unkown
HY-107760A	Decanoyl-RVKR-CMK TFA	Inhibitor	98.04%	Unkown
HY-107760	Decanoyl-RVKR-CMK	Inhibitor	98.02%	Unkown
HY-P1345	TLQP-21	Agonist	/	Unkown
HY-RS15643	VGF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	VGF	VGNC	VGNC:78767
Rattus norvegicus	VGF	RGD	RGD:69399
Canis familiaris	VGF	VGNC	VGNC:54090
Felis catus	VGF	VGNC	VGNC:107829
Bos taurus	VGF	VGNC	VGNC:36790
Mus musculus	VGF	MGD	MGI:1343180

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