2. Anti-infection
  3. HIV
  4. Decanoyl-RVKR-CMK

Decanoyl-RVKR-CMK  (Synonyms: DecRVKRcmk)

Cat. No.: HY-107760 Purity: 98.02%
Data Sheet
SDS
COA
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Solubility

In Vivo Dissolution Calculator

Help & FAQs

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Decanoyl-RVKR-CMK Chemical Structure

Decanoyl-RVKR-CMK Chemical Structure

CAS No. : 150113-99-8

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1 mg USD 260 In-stock
5 mg USD 650 In-stock
10 mg USD 1050 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Decanoyl-RVKR-CMK:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Decanoyl-RVKR-CMK

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication[1].

In Vitro

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell[1].
Decanoyl-RVKR-CMK (DecRVKRcmk) blocks regulated secretion of VGF[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL.
Concentration: 35 and 70 µΜ.
Incubation Time: 7 days.
Result: Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).
Molecular Weight

744.41

Formula

C34H66ClN11O5
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (134.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3433 mL 6.7167 mL 13.4335 mL
5 mM 0.2687 mL 1.3433 mL 2.6867 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3433 mL 6.7167 mL 13.4335 mL 33.5836 mL
5 mM 0.2687 mL 1.3433 mL 2.6867 mL 6.7167 mL
10 mM 0.1343 mL 0.6717 mL 1.3433 mL 3.3584 mL
15 mM 0.0896 mL 0.4478 mL 0.8956 mL 2.2389 mL
20 mM 0.0672 mL 0.3358 mL 0.6717 mL 1.6792 mL
25 mM 0.0537 mL 0.2687 mL 0.5373 mL 1.3433 mL
30 mM 0.0448 mL 0.2239 mL 0.4478 mL 1.1195 mL
40 mM 0.0336 mL 0.1679 mL 0.3358 mL 0.8396 mL
50 mM 0.0269 mL 0.1343 mL 0.2687 mL 0.6717 mL
60 mM 0.0224 mL 0.1119 mL 0.2239 mL 0.5597 mL
80 mM 0.0168 mL 0.0840 mL 0.1679 mL 0.4198 mL
100 mM 0.0134 mL 0.0672 mL 0.1343 mL 0.3358 mL
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Decanoyl-RVKR-CMK Related Classifications

Help & FAQs
  • How should lyophilized recombinant proteins be reconstituted and stored?

    1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss. 2. Taking 10 μg as an example, first add 20 μL of reconstituted solution provided by MCE and use a pipette to gently resuspend the lyophilized protein until it is fully dissolved.. (For most proteins, the reconstitution solution we provide is sterile water. If a diluent other than water is required, it will be indicated in the product's Certificate of Analysis (COA).). 3. Add an additional 80 μL of buffer/culture medium containing carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% trehalose), and then use a pipette to gently mix until uniform. The final concentration is should not be lower than 100 μg/mL. 4. Aliquot at least 20 μL per tube. 5. After aliquoting, store it frozen at a temperature ranging from -20ºC to -80ºC, and it can be preserved for 3 to 6 months.

  • How should solution-form recombinant proteins be stored?

    1. The product can be stored in its original form and diluted as needed upon use. 2. Alternatively, dilute with a buffer/culture medium containing a carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% alginate), mix well by pipetting, and ensure that

  • Why is it necessary to add carrier proteins?

    Carrier proteins are commonly added to enhance the stability of recombinant proteins, preventing them from adhering to the walls of the container during freezing or thawing processes. Plastic tubes have a certain adsorptive capacity for proteins, which may lead to difficulty in separating the protein from the tube walls, resulting in a decrease in the actual concentration of the protein in the solution and thus affecting its activity. To minimize such losses, it is recommended to add a commonly used carrier protein solution prior to the long-term storage of recombinant protein products.

  • Carrier protein types and options?

    In cases where the carrier protein is not expected to influence the experimental outcomes, an appropriate carrier protein, such as 0.1% BSA (Bovine Serum Albumin), 5% HSA (Human Serum Albumin), 10% FBS (Fetal Bovine Serum), or 5% trehalose, can be incorpo

Keywords:

Decanoyl-RVKR-CMK150113-99-8DecRVKRcmkHIVHuman immunodeficiency virusglycoproteinVGF glycoproteinVGFHIV-2 ROD infectionreplicationInhibitorinhibitorinhibit

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