WARS1 - tryptophanyl-tRNA synthetase 1 Gene

Homo sapiens

Also known as HMN9; WARS; IFI53; IFP53; GAMMA-2

Gene ID: 7453 | Gene type: protein coding

About WARS1

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:100,333,790-100,376,327 (from NCBI)

This gene has 44 transcripts (splice variants), 201 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in placenta (RPKM 128.2), appendix (RPKM 87.1) and 24 other tissues.

Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking Amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

WARS1 Products(4)

mRNA	Protein	Name
NM_004184.4	NP_004175.2	tryptophan--tRNA ligase, cytoplasmic isoform a
NM_173701.2	NP_776049.1	tryptophan--tRNA ligase, cytoplasmic isoform a
NM_213645.2	NP_998810.1	tryptophan--tRNA ligase, cytoplasmic isoform b
NM_213646.2	NP_998811.1	tryptophan--tRNA ligase, cytoplasmic isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase inhibitor activity	IDA IDA: Inferred from direct assay	22504299	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15628863	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	22504299	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	22504299	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22504299	GOA
enables tryptophan-tRNA ligase activity	IMP IMP: Inferred from mutant phenotype	28369220	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	22504299	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	22504299	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	22504299	GOA
involved in regulation of angiogenesis	IDA IDA: Inferred from direct assay	11773625	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	22504299	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	22504299	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WARS1 Protein Structure

WHEP-TRS

tRNA-synt_1b

0
100
200
300
400
471 a.a.

Protein Preferred Names

Protein Names

tryptophan--tRNA ligase, cytoplasmic

epididymis secretory sperm binding protein

Recombinant WARS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71134	WARS Protein, Human (His)	P23381 (M1-Q471)	≥95%
HY-P73540	WARS Protein, Human (sf9, His)	P23381 (P2-Q471)	≥95%

Related Diseases

Diseases

Alias

Neuronopathy, Distal Hereditary Motor, Type Ix

HMN9	Dhmn9
Neuropathy, Distal Hereditary Motor, Type Ix	Neuronopathy, Distal Hereditary Motor, Type 9
Distal Hereditary Motor Neuronopathy Type 9	Distal Hereditary Motor Neuropathy Type Ix
Neuronopathy, Distal Hereditary Motor, 9

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Developmental And Epileptic Encephalopathy 29

DEE29	Epileptic Encephalopathy, Early Infantile, 29
Eiee29	Developmental And Epileptic Encephalopathy, 29
Early Infantile Epileptic Encephalopathy 29	Encephalopathy, Developmental And Epileptic, Type 29

Charcot-Marie-Tooth Disease, Axonal, Type 2u

CMT2U	Charcot-Marie-Tooth Disease Axonal Type 2u
Charcot-Marie-Tooth Neuropathy, Type 2u	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2u
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2u	Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2u
Charcot-Marie-Tooth Neuropathy Type 2u	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Mars Mutation
Charcot-Marie-Tooth Disease 2u

Charcot-Marie-Tooth Disease, Axonal, Type 2d

Charcot-Marie-Tooth Disease Type 2d	CMT2D
Charcot-Marie-Tooth Disease, Type 2d	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2d
Charcot-Marie-Tooth Disease Neuronal Type 2d	Charcot-Marie-Tooth Neuropathy Type 2d
Charcot-Marie-Tooth Disease, Neuronal, Type 2d	Charcot-Marie-Tooth Neuropathy, Type 2d
Charcot-Marie-Tooth Disease 2d	Charcot-Marie-Tooth Disease Axonal Type 2d

Osteopetrosis, Autosomal Dominant 2

OPTA2	Autosomal Dominant Osteopetrosis 2
Osteopetrosis Autosomal Dominant Type 2	Osteopetrosis, Autosomal Dominant, Type Ii
Albers-Schonberg Osteopetrosis	Autosomal Dominant Albers-Schonberg Disease
Osteopetrosis	Marble Bones, Autosomal Dominant
Osteosclerosis Fragilis Generalisata	Albers-Schonberg Disease, Autosomal Dominant
Autosomal Dominant Osteopetrosis Type Ii	Albers-Schönberg Osteopetrosis
Autosomal Dominant Osteopetrosis Type 2	Marble Disease Autosomal Dominant
Osteopetrosis, Autosomal Dominant, Type 2

Autosomal Dominant Distal Hereditary Motor Neuronopathy

Autosomal Dominant Distal Hereditary Motor Neuropathy	Autosomal Dominant Dhmn
Autosomal Dominant Distal Spinal Muscular Atrophy

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15739	WARS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	WARS1	VGNC	VGNC:48331
Mus musculus	WARS1	MGD	MGI:104630
Rattus norvegicus	WARS1	RGD	RGD:1308278
Bos taurus	WARS1	VGNC	VGNC:36863
Felis catus	WARS1	VGNC	VGNC:66999
Macaca mulatta	WARS1	VGNC	VGNC:78779
Others	WARS1	NCBI

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