1. Gene
  2. WNT11 - Wnt family member 11 Gene

WNT11 - Wnt family member 11 Gene

Homo sapiens

Also known as HWNT11

Gene ID: 7481 | Gene type: protein coding

About WNT11

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:76,186,325-76,210,761 (from NCBI)

This gene has 3 transcripts (splice variants), 224 orthologues and 18 paralogues. Broad expression in fat (RPKM 7.4), adrenal (RPKM 3.7) and 15 other tissues.

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]

WNT11 Products(1)

mRNA Protein Name
NM_004626.3 NP_004617.2 protein Wnt-11 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein kinase activator activity IMP
IMP: Inferred from mutant phenotype
20219091 GOA
Biological Process GO Annotation Evidence Reference Source
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
9757009 GOA
involved in cloacal septation IEP
IEP: Inferred from expression pattern
9757009 GOA
involved in embryonic skeletal system development IEP
IEP: Inferred from expression pattern
9757009 GOA
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
20103596 GOA
involved in lung-associated mesenchyme development IEP
IEP: Inferred from expression pattern
9757009 GOA
involved in mesonephric duct development IEP
IEP: Inferred from expression pattern
9757009 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20103596 GOA
involved in neuroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
20219091 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19847889 GOA
involved in secondary palate development IMP
IMP: Inferred from mutant phenotype
18413325 GOA
involved in signal transduction IMP
IMP: Inferred from mutant phenotype
20219091 GOA
involved in ureteric bud morphogenesis IEP
IEP: Inferred from expression pattern
9757009 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20103596 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT11 Protein Structure

wnt

wnt: wnt family (45 - 354)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

protein Wnt-11

wingless-type MMTV integration site family, member 11

WNT11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
WNT11 O96014 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
WNT11 O96014 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
WNT11 O96014 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
WNT11 O96014 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
WNT11 O96014 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra
WNT11 O96014 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
WNT11 O96014 KRTAP1-5 Homo sapiens Q9BYS1
Y2H Array
32296183
Intra
WNT11 O96014 KRTAP1-5 Homo sapiens Q9BYS1
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 KRTAP1-5 Homo sapiens Q9BYS1
Validated Y2H
32296183
Intra
WNT11 O96014 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
WNT11 O96014 KRTAP12-3 Homo sapiens P60328
Validated Y2H
32296183
Intra
WNT11 O96014 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
WNT11 O96014 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
WNT11 O96014 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
WNT11 O96014 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 KRTAP5-7 Homo sapiens Q6L8G8
Validated Y2H
32296183
Intra
WNT11 O96014 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra
WNT11 O96014 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra
WNT11 O96014 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra
WNT11 O96014 KRTAP5-8 Homo sapiens O75690
Y2H Array
32296183
Intra
WNT11 O96014 KRTAP5-8 Homo sapiens O75690
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
WNT11 O96014 KRTAP5-9 Homo sapiens P26371
Validated Y2H
32296183
Intra
WNT11 O96014 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
WNT11 O96014 RASSF10 Homo sapiens A6NK89
Y2H Array
32296183
Intra
WNT11 O96014 RASSF10 Homo sapiens A6NK89
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra
WNT11 O96014 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
WNT11 O96014 MDFI Homo sapiens Q99750
Y2H Array
30886144
Intra
WNT11 O96014 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
WNT11 O96014 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
32296183
Intra
WNT11 O96014 CCNDBP1 Homo sapiens O95273
Y2H Array
32296183
Intra
WNT11 O96014 FUCA2 Homo sapiens Q9BTY2
Y2H Array
32296183
Intra
WNT11 O96014 FUCA2 Homo sapiens Q9BTY2
Validated Y2H
32296183
Intra
WNT11 O96014 FUCA2 Homo sapiens Q9BTY2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Renal Hypoplasia
Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Fetal Face Syndrome

Robinow Dwarfism

Mesomelic Dwarfism-Small Genitalia Syndrome

Robinow-Silverman-Smith Syndrome

Costovertebral Segmentation Defect With Mesomelia

Covesdem Syndrome

Robinow'S Syndrome

Robinow-Silverman Syndrome

Norrie Disease

Atrophia Bulborum Hereditaria

Episkopi Blindness

Pseudoglioma

ND

Norrie-Warburg Disease

Anderson-Warburg Syndrome

Fetal Iritis Syndrome

Norrie Syndrome

Norrie-Warburg Syndrome

Ndp

Congenital Progressive Oculo-Acoustico-Cerebral Degeneration

Norrie'S Disease

Oligophrenia Microphthalmus

Pseudoglioma Congenita

Whitnall-Norman Syndrome

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy

Fevr

Criswick-Schepens Syndrome

Exudative Vitreoretinopathy, Familial

Vitreoretinopathy, Exudative )

Exudative Vitreoretinopathy 1

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Renal Hypodysplasia/Aplasia 1

Renal Agenesis

Renal Adysplasia

Renal Aplasia

RHDA1

Hereditary Renal Aplasia

Hra

Hereditary Urogenital Adysplasia

Hypodysplasia/Aplasia, Renal, Type 1

Congenital Absence Of Kidneys Syndrome

Congenital Absence Of Kidney

Aplastic Kidney

Fallopian Tube Serous Adenocarcinoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect

Taussig-Bing Syndrome

Dextrotransposition Of Aorta

Taussig-Bing Syndrome Or Defect

Dorv

Dorv With Subpulmonary Vsd

Dorv-Tga

Double Outlet Right Ventricle With Transposition Of The Great Arteries

Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type

Taussig-Bing Heart

Taussig-Bing Malformation

Taussig-Bing Complex

Taussig-Bing Defect

Taussig-Bing

Double Outlet Right Ventricle With Remote Ventricular Septal Defect

Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect

Double Outlet Right Ventricle With Non-Committed Interventricular Communication

Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis

Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate

Cakut

Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1

Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1

Orofacial Cleft

Cleft, Orofacial

Tooth Agenesis

Oligodontia

Hypodontia

Selective Tooth Agenesis

Tooth Agenesis, Selective

Familial Tooth Agenesis

Anodontia

Congenital Absence Of One Tooth

Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta WNT11 VGNC VGNC:78795
Mus musculus WNT11 MGD MGI:101948
Bos taurus WNT11 VGNC VGNC:36955
Canis familiaris WNT11 VGNC VGNC:48421
Rattus norvegicus WNT11 RGD RGD:621463
Felis catus WNT11 VGNC VGNC:67082