XRCC2 - X-ray repair cross complementing 2 Gene

Homo sapiens

Also known as FANCU; POF17; SPGF50

Gene ID: 7516 | Gene type: protein coding

About XRCC2

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:152,644,776-152,676,141 (from NCBI)

This gene has 4 transcripts (splice variants), 191 orthologues, 6 paralogues and is associated with 6 phenotypes. Broad expression in testis (RPKM 1.4), bone marrow (RPKM 1.0) and 22 other tissues.

Summary

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]

XRCC2 Products(1)

mRNA	Protein	Name
NM_005431.2	NP_005422.1	DNA repair protein XRCC2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to four-way junction DNA binding	IDA IDA: Inferred from direct assay	20207730	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10749867	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA repair	IGI IGI: Inferred from genetic interaction	10422536	GOA
involved in DNA strand invasion	IDA IDA: Inferred from direct assay	11834724	GOA
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	21276791	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	23149936	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21276791	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Rad51B-Rad51C-Rad51D-XRCC2 complex	IDA IDA: Inferred from direct assay	11751635	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21276791	GOA
located in replication fork	IDA IDA: Inferred from direct assay	20207730	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XRCC2 Protein Structure

Rad51

0
100
200
280 a.a.

Protein Preferred Names

Protein Names

DNA repair protein XRCC2

X-ray repair complementing defective repair in Chinese hamster cells 2

XRCC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	XRCC2	O43543	RAD51C	Homo sapiens	O43502	Anti Tag CoIP	28514442
Intra	XRCC2	O43543	RAD51C	Homo sapiens	O43502	Anti Bait CoIP	11842113
Intra	XRCC2	O43543	RAD51C	Homo sapiens	O43502	Anti Tag CoIP	33961781
Intra	XRCC2	O43543	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	XRCC2	O43543	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Premature Ovarian Failure 17

POF17

Ovarian Failure, Premature, Type 17

Spermatogenic Failure 50

SPGF50

Fanconi Anemia, Complementation Group U

Fanconi Anemia Complementation Group U

FANCU

Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Inherited Cancer-Predisposing Syndrome

Hereditary Cancer-Predisposing Syndrome

Bap1 Tumor Predisposition Syndrome

Bap1-Related Tumor Predisposition Syndrome	Common Syndrome
Bap1 Cancer Syndrome	Bap1-Tpds
Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms	Tumor Predisposition Syndrome
Tumor Susceptibility Linked To Germline Bap1 Mutations	Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms
Tumor Predisposition

Short Stature, Microcephaly, And Endocrine Dysfunction

SSMED

Hereditary Breast Cancer

Familial Breast Cancer	Familial Breast Carcinoma
Hereditary Breast Carcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Cervix Melanoma

Infertility

Lipodystrophy, Familial Partial, Type 6

FPLD6	Lipe-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 6	Lipe-Related Fpld
Lipodystrophy, Familial Partial, Associated With Lipe Mutations	Familial Partial Lipodystrophy Associated With Lipe Mutations
Lipodystrophy, Familial Partial, 6

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15897	XRCC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	XRCC2	VGNC	VGNC:48466
Mus musculus	XRCC2	MGD	MGI:1927345
Felis catus	XRCC2	VGNC	VGNC:67117
Macaca mulatta	XRCC2	VGNC	VGNC:78813
Bos taurus	XRCC2	VGNC	VGNC:37003
Rattus norvegicus	XRCC2	RGD	RGD:1564823

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