ZNF2 - zinc finger protein 2 Gene

Homo sapiens

Also known as A1-5; ZNF661; Zfp661

Gene ID: 7549 | Gene type: protein coding

About ZNF2

Cytogenetic location: 2q11.1 Genomic coordinates (GRCh38): 2:95,165,809-95,184,317 (from NCBI)

This gene has 5 transcripts (splice variants), 95 orthologues and 174 paralogues. Ubiquitous expression in testis (RPKM 1.8), thyroid (RPKM 1.6) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

ZNF2 Products(5)

mRNA	Protein	Name
NM_001017396.3	NP_001017396.1	zinc finger protein 2 isoform b
NM_001282398.2	NP_001269327.1	zinc finger protein 2 isoform c
NM_001291604.2	NP_001278533.1	zinc finger protein 2 isoform d
NM_001291605.2	NP_001278534.1	zinc finger protein 2 isoform e
NM_021088.4	NP_066574.2	zinc finger protein 2 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF2 Protein Structure

KRAB

zf-H2C2_2

0
100
200
300
400
426 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 2

zinc finger protein 2.2

ZNF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF2	Q9BSG1	TRIM41	Homo sapiens	Q8WV44	Y2H Array	32296183
Intra	ZNF2	Q9BSG1	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	32296183
Intra	ZNF2	Q9BSG1	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	ZNF2	Q9BSG1	DVL3	Homo sapiens	Q92997	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Holoprosencephaly 5

HPE5	Holoprosencephaly-5
Holoprosencephaly, Type 5

Hemophagocytic Lymphohistiocytosis, Familial, 3

Familial Hemophagocytic Lymphohistiocytosis 3	FHL3
Hplh3	Hlh3
Lymphohistiocytosis, Hemophagocytic, Familial, Type 3

Fungal Meningitis

Meningitis, Fungal

Mycotic Meningitis

Cryptococcal Meningitis

Meningitis, Cryptococcal

Meningitis Cryptococcal

Cryptococcosis

Cryptococcus Neoformans Infection	Torulosis
Busse-Buschke'S Disease	Cryptococcal Infection
European Cryptococcosis	Torula
Infection By Cryptococcus Neoformans	Cryptococcosis Infection
European Blastomycosis	European Blastomycotic Infection
European Blastomycoses Infection	Torula Histolytica Infection

Hemophagocytic Lymphohistiocytosis, Familial, 1

Familial Hemophagocytic Lymphohistiocytosis	Fhl
Familial Erythrophagocytic Lymphohistiocytosis	Hemophagocytic Syndrome
FHL1	Hplh1
Hlh1	Fel
Familial Hemophagocytic Lymphohistiocytosis 1	Primary Hemophagocytic Lymphohistiocytosis
Familial Hlh	Hlh
Familial Hemophagocytic Lymphocytosis	Hemophagocytic Lymphohistiocytosis, Familial
Reticulosis, Familial Histiocytic	Hemophagocytic Reticulosis, Familial
Erythrophagocytic Lymphohistiocytosis, Familial	Familial Histiocytic Reticulosis
Familial Hemophagocytic Histiocytosis	Familial Hemophagocytic Reticulosis
Fhlh	Hplh
Primary Hemophagocytic Hymphohistiocytosis	Genetic Hemophagocytic Lymphohistiocytosis
Hemophagocytic Lymphohistiocytosis	Familial Hemophagocytic Lymphohistiocytosis Type 1

Potocki-Lupski Syndrome

PTLS	Chromosome 17p11.2 Duplication Syndrome
17p11.2 Microduplication Syndrome	Duplication 17p11.2 Syndrome
Trisomy 17p11.2	Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))
17p11.2 Duplication Syndrome	Dup(17)(P11.2p11.2)
Pls	Chromosome 17, Trisomy 17p11 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16108	ZNF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZNF2	RGD	RGD:6500748
Macaca mulatta	ZNF2	VGNC	VGNC:106247
Bos taurus	ZNF2	VGNC	VGNC:37221
Mus musculus	ZNF2	MGD	MGI:1919430
Others	ZNF2	NCBI

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