1. Gene
  2. SCG2 - secretogranin II Gene

SCG2 - secretogranin II Gene

Homo sapiens

Also known as SN; CHGC; EM66; SgII

Gene ID: 7857 | Gene type: protein coding

About SCG2

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:223,596,940-223,602,361 (from NCBI)

This gene has 3 transcripts (splice variants) and 254 orthologues. Biased expression in adrenal (RPKM 212.1), brain (RPKM 97.1) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide Hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]

SCG2 Products(1)

mRNA Protein Name
NM_003469.5 NP_003460.2 secretogranin-2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chemoattractant activity IDA
IDA: Inferred from direct assay
9473216 GOA
enables cytokine activity IDA
IDA: Inferred from direct assay
14970115 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
Biological Process GO Annotation Evidence Reference Source
involved in MAPK cascade IDA
IDA: Inferred from direct assay
14970115 GOA
involved in angiogenesis IDA
IDA: Inferred from direct assay
14970115 GOA
involved in eosinophil chemotaxis IDA
IDA: Inferred from direct assay
9473216 GOA
involved in induction of positive chemotaxis IDA
IDA: Inferred from direct assay
9473216 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
9473216 GOA
involved in negative regulation of endothelial cell apoptotic process IDA
IDA: Inferred from direct assay
14970115 GOA
involved in negative regulation of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
14970115 GOA
involved in positive chemotaxis IDA
IDA: Inferred from direct assay
9473216 GOA
involved in positive regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
14970115 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
9473216 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCG2 Protein Structure

Granin

Granin: Granin (chromogranin or secretogranin) (27 - 614)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 617 a.a.
Protein Preferred Names Protein Names

secretogranin-2

chromogranin-C

SCG2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SCG2 P13521 UBQLN1 Homo sapiens Q9UMX0
Y2H
21516116
Intra
SCG2 P13521 UBQLN1 Homo sapiens Q9UMX0 32296183
Intra
SCG2 P13521 ATRIP Homo sapiens Q8WXE1 25416956
Intra
SCG2 P13521 ATRIP Homo sapiens Q8WXE1 25416956
Intra
SCG2 P13521 ATRIP Homo sapiens Q8WXE1 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SCG2 Proteins

Cat. No. Product Name Accession Purity
HY-P70134 Secretogranin-2 Protein, Human (HEK293, His) P13521 (S29-M617) ≥95%

Related Diseases

Diseases Alias
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Intracranial Primitive Neuroectodermal Tumor

Intracranial Pnet

Intracranial Primitive Neuroectodermal Neoplasm

Insulinoma

Islet Cell Adenoma

Insulin-Producing Tumor Of Islet Cells

Adenoma Islet Cell

Islet Cell Tumor

Experimental Organism Islet Cell Adenoma Neoplasm

Ganglioneuroma
Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Collagenous Colitis

Colitis, Collagenous

Microscopic Colitis, Collagenous Type

Malignant Pheochromocytoma

Pheochromocytoma, Malignant

Adrenal Medulla Cancer

Adrenal Medulla Neoplasm

Adrenal Medulla Tumor

Malignant Neoplasm Of Adrenal Medulla

Malignant Tumor Of The Adrenal Medulla

Adrenal Medulla Carcinoma

Neoplasm Of Adrenal Medulla

Neuroendocrine Tumor

Neuroendocrine Neoplasm

Neuroendocrine Tumors

Carcinoma, Neuroendocrine

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus SCG2 VGNC VGNC:64908
Mus musculus SCG2 MGD MGI:103033
Canis familiaris SCG2 VGNC VGNC:45905
Rattus norvegicus SCG2 RGD RGD:3626
Bos taurus SCG2 VGNC VGNC:34332
Macaca mulatta SCG2 VGNC VGNC:76977
Others SCG2 NCBI