2. Gene
  3. Sp2 - Sp2 transcription factor Gene

Sp2 - Sp2 transcription factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mKIAA0048; 4930480I16Rik

Gene ID: 78912 | Gene type: protein coding

About Sp2

Summary

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the Other Sp proteins. The protein can act as a transcriptional activator or repressor, depending on the promoter and cell type. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Sp2 Products(4)

mRNA Protein Name
NM_001080964.2 NP_001074433.1 transcription factor Sp2 isoform 2
NM_001363225.1 NP_001350154.1 transcription factor Sp2 isoform 3
NM_001363226.1 NP_001350155.1 transcription factor Sp2 isoform 3
NM_030220.4 NP_084496.2 transcription factor Sp2 isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within circulatory system development IMP
IMP: Inferred from mutant phenotype
20221402 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
20221402 MGI
acts upstream of or within fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
20221402 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
20221402 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
20221402 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor Sp2

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-155176 SP-2-225 Inhibitor / Unkown
HY-162258 AChE-IN-57 Inhibitor / Unkown
HY-173132 AKR1Cs-IN-1 Inhibitor / Unkown
HY-N10208 Aspericin C / Unkown
HY-P10604 SP2 Inhibitor / Unkown
HY-P5870 KTX-Sp2 Inhibitor / Unkown
HY-RS13605 SP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sp2 NCBI NCBI:6668
Macaca fascicularis Sp2 NCBI NCBI:102145464
Rattus norvegicus Sp2 NCBI NCBI:303499