SP2 - Sp2 transcription factor Gene

Homo sapiens

Gene ID: 6668 | Gene type: protein coding

About SP2

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,896,236-47,931,731 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 4.3), spleen (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]

SP2 Products(1)

mRNA	Protein	Name
NM_003110.6	NP_003101.3	transcription factor Sp2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10744779	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10744779	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	17827154	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10744779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SP2 Protein Structure

zf-H2C2_2

0
100
200
300
400
500
613 a.a.

Protein Preferred Names

Protein Names

transcription factor Sp2

Related Diseases

Diseases

Alias

Basidiobolomycosis

Infection By Basidiobolus

Subcutaneous Mucoromycosis Due To Basidiobolus Ranarum

Dracunculiasis

Guinea Worm Disease	Dracontiasis
Dracunculosis	Infection By Dracunculus Medinensis
Gwd	Guinea Worm Infection
Parasitic Infection Caused By Dracunculus Medinensis	Medina Worm Disease
Medinensis	Medina Worm Infestation
Dracunculus Medinensis Infestation	Guinea Worm Infestation

Large Intestine Adenocarcinoma

Adenocarcinoma Of Large Intestine

Leukodystrophy, Hypomyelinating, 2

Pmld1	Hypomyelinating Leukodystrophy 2
HLD2	Pelizaeus-Merzbacher-Like Disease 1
Pelizaeus-Merzbacher-Like Disease Due To Gjc2 Mutation	Pelizaeus-Merzbacher-Like Disease Type 1
Pelizaeus-Merzbacher-Like Disease, 1	Pelizaeus Merzbacher Like Disease
Pelizaeus-Merzbacher-Like Disease	Pmld - Pelizaeus Merzbacher Like Disease
Pelizaeus-Merzbacher-Like Disease Autosomal Recessive Type 1	Pmldar1
Leukodystrophy, Hypomyelinating, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155176	SP-2-225	Inhibitor	/	Unkown
HY-162258	AChE-IN-57	Inhibitor	/	Unkown
HY-N10208	Aspericin C		/	Unkown
HY-P5870	KTX-Sp2	Inhibitor	/	Unkown
HY-RS13605	SP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-137646	Sp-2-Cl-cAMPS		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SP2	MGD	MGI:1926162
Canis familiaris	SP2	VGNC	VGNC:46686
Felis catus	SP2	VGNC	VGNC:65586
Macaca mulatta	SP2	VGNC	VGNC:77845
Rattus norvegicus	SP2	RGD	RGD:1592078
Bos taurus	SP2	VGNC	VGNC:35153
Macaca fascicularis	SP2	NCBI	NCBI:102145464
Others	SP2	NCBI

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