CYREN - cell cycle regulator of NHEJ Gene

Homo sapiens

Also known as MRI; MRI-2; C7orf49

Gene ID: 78996 | Gene type: protein coding

About CYREN

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,092,303-135,172,469 (from NCBI)

This gene has 14 transcripts (splice variants) and 96 orthologues. Ubiquitous expression in lung (RPKM 6.0), spleen (RPKM 6.0) and 25 other tissues.

Summary

Involved in double-strand break repair via nonhomologous end joining and negative regulation of double-strand break repair via nonhomologous end joining. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CYREN Products(11)

mRNA	Protein	Name
NM_001243749.2	NP_001230678.1	cell cycle regulator of non-homologous end joining isoform 2
NM_001243751.2	NP_001230680.1	cell cycle regulator of non-homologous end joining isoform 2
NM_001243752.2	NP_001230681.1	cell cycle regulator of non-homologous end joining isoform 2
NM_001243753.2	NP_001230682.1	cell cycle regulator of non-homologous end joining isoform 2
NM_001243754.2	NP_001230683.1	cell cycle regulator of non-homologous end joining isoform 3
NM_001243755.2	NP_001230684.1	cell cycle regulator of non-homologous end joining isoform 3
NM_001305629.2	NP_001292558.1	cell cycle regulator of non-homologous end joining isoform 4
NM_001305630.2	NP_001292559.1	cell cycle regulator of non-homologous end joining isoform 5
NM_001363329.2	NP_001350258.1	cell cycle regulator of non-homologous end joining isoform 1
NM_001363330.2	NP_001350259.1	cell cycle regulator of non-homologous end joining isoform 1
NM_024033.4	NP_076938.2	cell cycle regulator of non-homologous end joining isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24610814	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	24610814	GOA
involved in negative regulation of double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	28959974	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24610814	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24610814	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYREN Protein Structure

MRI

0
100
157 a.a.

Protein Preferred Names

Protein Names

cell cycle regulator of non-homologous end joining

modulator of retrovirus infection homolog

Related Diseases

Diseases

Alias

Petrositis

Acute Petrositis	Chronic Petrositis
Inflammation Of Petrous Bone	Osteitis Of Petrous Bone
Osteomyelitis Of Petrous Bone

Epilepsy, Familial Temporal Lobe, 3

Epilepsy, Familial Mesial Temporal Lobe	Fmtle
Familial Temporal Lobe Epilepsy 3	ETL3
Familial Mesial Temporal Lobe Epilepsy

Bn2 Diffuse Large B-Cell Lymphoma

Bn2 Dlbcl

Doid:0081064

Telangiectatic Osteogenic Sarcoma

Telangiectatic Osteosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03490	CYREN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CYREN	VGNC	VGNC:59049
Macaca mulatta	CYREN	VGNC	VGNC:81301
Rattus norvegicus	CYREN	RGD	RGD:1563238
Bos taurus	CYREN	VGNC	VGNC:52721
Mus musculus	CYREN	MGD	MGI:1925662
Felis catus	CYREN	VGNC	VGNC:102031

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