METTL16 - methyltransferase 16, N6-methyladenosine Gene

Homo sapiens

Also known as METT10D

Gene ID: 79066 | Gene type: protein coding

About METTL16

This gene has 10 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in ovary (RPKM 7.5), thyroid (RPKM 6.7) and 25 other tissues.

Summary

Enables RNA binding activity and RNA methyltransferase activity. Involved in RNA modification and regulation of mRNA metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

METTL16 Products(1)

mRNA	Protein	Name
NM_024086.4	NP_076991.3	RNA N6-adenosine-methyltransferase METTL16

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	27872311	GOA
enables RNA stem-loop binding	IDA IDA: Inferred from direct assay	28525753	GOA
enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity	IDA IDA: Inferred from direct assay	28525753	GOA
enables U6 snRNA 3'-end binding	IDA IDA: Inferred from direct assay	28525753	GOA
enables mRNA m(6)A methyltransferase activity	IDA IDA: Inferred from direct assay	28525753	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of S-adenosylmethionine biosynthetic process	IDA IDA: Inferred from direct assay	28525753	GOA
involved in mRNA processing	IDA IDA: Inferred from direct assay	30197297	GOA
involved in negative regulation of 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	28525753	GOA
involved in post-transcriptional regulation of gene expression	IDA IDA: Inferred from direct assay	28525753	GOA
involved in regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28525753	GOA
involved in snRNA (adenine-N6)-methylation	IDA IDA: Inferred from direct assay	28525753	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	31940410	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27872311	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL16 Protein Structure

Methyltransf_10

0
100
200
300
400
500
562 a.a.

Protein Preferred Names

Protein Names

RNA N6-adenosine-methyltransferase METTL16

N6-adenosine-methyltransferase METTL16

Related Diseases

Diseases

Alias

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161402	METTL16-IN-1	Inhibitor	99.22%	Unkown
HY-162082	METTL1-WDR4-IN-2	Inhibitor	99.71%	Unkown
HY-RS08357	METTL16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	METTL16	MGD	MGI:1914743
Felis catus	METTL16	VGNC	VGNC:63460
Macaca mulatta	METTL16	VGNC	VGNC:74603
Bos taurus	METTL16	VGNC	VGNC:55844
Canis familiaris	METTL16	VGNC	VGNC:43172
Rattus norvegicus	METTL16	RGD	RGD:1593242

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