2. Epigenetics
  3. DNA Methyltransferase
  4. METTL16-IN-1

METTL16-IN-1 (Compound 45) is a potent METTL16 inhibitor with an IC50 value of 1.7 μM and a Kd value of 1.35 μM.

For research use only. We do not sell to patients.

METTL16-IN-1 Chemical Structure

METTL16-IN-1 Chemical Structure

Size Price Stock Quantity
1 mg USD 250 In-stock
5 mg USD 625 In-stock
10 mg USD 937 In-stock
25 mg USD 1760 In-stock
50 mg USD 2630 In-stock
100 mg USD 3900 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

METTL16-IN-1 Related Antibodies

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  • Purity & Documentation

  • References

  • Customer Review

Description

METTL16-IN-1 (Compound 45) is a potent METTL16 inhibitor with an IC50 value of 1.7 μM and a Kd value of 1.35 μM[1].

Molecular Weight

522.35

Formula

C19H12BrN3O6S2
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C(O)C1=CC=C(S(=O)(NC(S/C2=C3C(N(C)C4=C\3C=C(Br)C=C4)=O)=NC2=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (191.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9144 mL 9.5721 mL 19.1443 mL
5 mM 0.3829 mL 1.9144 mL 3.8289 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (9.57 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.22%

COA (254 KB) HNMR (291 KB) RP-HPLC (261 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9144 mL 9.5721 mL 19.1443 mL 47.8606 mL
5 mM 0.3829 mL 1.9144 mL 3.8289 mL 9.5721 mL
10 mM 0.1914 mL 0.9572 mL 1.9144 mL 4.7861 mL
15 mM 0.1276 mL 0.6381 mL 1.2763 mL 3.1907 mL
20 mM 0.0957 mL 0.4786 mL 0.9572 mL 2.3930 mL
25 mM 0.0766 mL 0.3829 mL 0.7658 mL 1.9144 mL
30 mM 0.0638 mL 0.3191 mL 0.6381 mL 1.5954 mL
40 mM 0.0479 mL 0.2393 mL 0.4786 mL 1.1965 mL
50 mM 0.0383 mL 0.1914 mL 0.3829 mL 0.9572 mL
60 mM 0.0319 mL 0.1595 mL 0.3191 mL 0.7977 mL
80 mM 0.0239 mL 0.1197 mL 0.2393 mL 0.5983 mL
100 mM 0.0191 mL 0.0957 mL 0.1914 mL 0.4786 mL
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METTL16-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

METTL16-IN-1DNA MethyltransferaseDNMTsDNA MTasessmall-molecule inhibitorRNA modificationRNA-binding proteinpost-transcriptional regulationprotein-RNA interactionInhibitorinhibitorinhibit

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