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  3. MAPKAP1 - MAPK associated protein 1 Gene

MAPKAP1 - MAPK associated protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MIP1; SIN1; JC310; SIN1b; SIN1g

Gene ID: 79109 | Gene type: protein coding

About MAPKAP1

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:125,437,394-125,707,208 (from NCBI)

This gene has 20 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 18.8), testis (RPKM 17.4) and 25 other tissues.

Summary

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]

MAPKAP1 Products(6)

mRNA Protein Name
NM_001006617.3 NP_001006618.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 1
NM_001006618.2 NP_001006619.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 5
NM_001006619.2 NP_001006620.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 3
NM_001006620.2 NP_001006621.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 4
NM_001006621.2 NP_001006622.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 4
NM_024117.4 NP_077022.1 target of rapamycin complex 2 subunit MAPKAP1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
29567957 GOA
enables phosphatidic acid binding IDA
IDA: Inferred from direct assay
17303383 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
17303383 GOA
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
17303383 GOA
enables phosphatidylinositol-3,5-bisphosphate binding IDA
IDA: Inferred from direct assay
17303383 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
17303383 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24365180 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21177249 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
17303383 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
17303383 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17303383 GOA
part of TORC2 complex IPI
IPI: Inferred from physical interaction
17461779 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17303383 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPKAP1 Protein Structure

SIN1

SIN1: Stress-activated map kinase interacting protein 1 (SIN1) (18 - 481)

  • 0
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  • 200
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  • 400
  • 522 a.a.
Protein Preferred Names Protein Names

target of rapamycin complex 2 subunit MAPKAP1

MEKK2-interacting protein 1

Related Diseases

Diseases Alias
Short Syndrome

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay

Aarskog-Ose-Pande Syndrome

Lipodystrophy, Partial, With Rieger Anomaly And Short Stature

Lipodystrophy-Rieger Anomaly-Diabetes Syndrome

Rieger Anomaly-Partial Lipodystrophy Syndrome

Partial Lipodystrophy With Rieger Anomaly And Short Stature

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay

Growth Retardation-Rieger Anomaly

Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay

SHORTS
Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy

Severe Myoclonic Epilepsy In Infancy

Smei

Epileptic Encephalopathy, Early Infantile, 6

DRVT

Developmental And Epileptic Encephalopathy 6a

Dee6a

Eiee6

Developmental And Epileptic Encephalopathy, 6

Dee6

Developmental And Epileptic Encephalopathy 6

Early Infantile Epileptic Encephalopathy 6

Myoclonic Epilepsy, Severe, Of Infancy

Sme

Severe Myoclonus Epilepsy Of Infancy

Borderline Smei

Smeb

Smeb-M

Smeb-O

Smeb-Sw

Smei-Borderland

Smei-Borderland More Than One Feature

Smei-Borderland-Myoclonic Seizures

Smei-Borderland-Spike Wave

Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures

ICEGTC

Infantile Severe Myoclonic Epilepsy

Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N1326 Santamarine / Unkown
HY-RS08130 MAPKAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-N1190 DL-Syringaresinol Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAPKAP1 MGD MGI:2444554
Felis catus MAPKAP1 VGNC VGNC:63382
Bos taurus MAPKAP1 VGNC VGNC:31228
Rattus norvegicus MAPKAP1 RGD RGD:1305363
Macaca mulatta MAPKAP1 VGNC VGNC:74531
Canis familiaris MAPKAP1 VGNC VGNC:43005