DHX58 - DExH-box helicase 58 Gene

Homo sapiens

Also known as LGP2; RLR-3; D11LGP2; D11lgp2e

Gene ID: 79132 | Gene type: protein coding

About DHX58

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,101,411-42,112,714 (from NCBI)

This gene has 8 transcripts (splice variants), 242 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 10.6), testis (RPKM 8.8) and 25 other tissues.

Summary

Enables double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in negative regulation of defense response and negative regulation of type I interferon production. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DHX58 Products(1)

mRNA	Protein	Name
NM_024119.3	NP_077024.2	ATP-dependent RNA helicase DHX58

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	19211564	GOA
enables RNA helicase activity	IMP IMP: Inferred from mutant phenotype	19211564	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	18411269	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17190814	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	18411269	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	19278996	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic pattern recognition receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19211564	GOA
involved in negative regulation of MDA-5 signaling pathway	IMP IMP: Inferred from mutant phenotype	21187438	GOA
involved in negative regulation of RIG-I signaling pathway	IDA IDA: Inferred from direct assay	18411269	GOA
involved in negative regulation of RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	21187438	GOA
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	21525357	GOA
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	21525357	GOA
involved in regulation of innate immune response	IDA IDA: Inferred from direct assay	18411269	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHX58 Protein Structure

ResIII

Helicase_C

RIG-I_C-RD

0
200
400
600
678 a.a.

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DHX58

probable ATP-dependent RNA helicase DHX58

ATP-dependent helicase LGP2

DHX58 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DHX58	Q96C10	DHX30	Homo sapiens	Q7L2E3	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	EIF6	Homo sapiens	P56537	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	EIF2AK2	Homo sapiens	P19525	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	STAU2	Homo sapiens	Q9NUL3	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	NKRF	Homo sapiens	O15226	Anti Tag CoIP	21903422
Cross	DHX58	Q96C10	P/V	Simian virus 5	P11207	Anti Tag CoIP	19403670
Cross	DHX58	Q96C10	P/V	Measles virus	Q9EMA9	Anti Tag CoIP	19403670

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Ileum Cancer

Ileal Neoplasm	Malignant Neoplasm Of Ileum
Ileal Cancer	Ileal Neoplasms

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Keratitis, Hereditary

Keratitis	Autosomal Dominant Keratitis
Hereditary Keratitis	Dominantly Inherited Keratitis
Keratitis Hereditary	KERH

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03759	DHX58 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DHX58	VGNC	VGNC:39951
Rattus norvegicus	DHX58	RGD	RGD:1310093
Macaca mulatta	DHX58	VGNC	VGNC:71815
Mus musculus	DHX58	MGD	MGI:1931560
Felis catus	DHX58	VGNC	VGNC:61486
Bos taurus	DHX58	VGNC	VGNC:28058
Others	DHX58	NCBI

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