FCRL2 - Fc receptor like 2 Gene

Homo sapiens

Also known as FCRH2; IFGP4; IRTA4; SPAP1; CD307b; SPAP1A; SPAP1B; SPAP1C

Gene ID: 79368 | Gene type: protein coding

About FCRL2

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:157,745,733-157,777,132 (from NCBI)

This gene has 5 transcripts (splice variants), 42 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 14.2), spleen (RPKM 13.1) and 7 other tissues.

Summary

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]

FCRL2 Products(2)

mRNA	Protein	Name
NM_001159488.2	NP_001152960.1	Fc receptor-like protein 2 isoform 2 precursor
NM_030764.4	NP_110391.2	Fc receptor-like protein 2 isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	11162587	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	11162587	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	16849395	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCRL2 Protein Structure

Ig_2

Ig_3

Ig_2

Ig_3

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

Fc receptor-like protein 2

IFGP family protein 4

FCRL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FCRL2	Q96LA5	METAP2	Homo sapiens	P50579	Anti Tag CoIP	28514442
Intra	FCRL2	Q96LA5	METAP2	Homo sapiens	P50579	Anti Tag CoIP	33961781
Intra	FCRL2	Q96LA5	NCK2	Homo sapiens	O43639	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FCRL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76924	FCRL2 Protein, Human (HEK293, His)	Q96LA5-1/NP_110391.2 (L20-D395)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04843	FCRL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FCRL2	VGNC	VGNC:107873
Mus musculus	FCRL2	MGD	MGI:1933397
Macaca mulatta	FCRL2	VGNC	VGNC:72509
Rattus norvegicus	FCRL2	RGD	RGD:1306885
Canis familiaris	FCRL2	VGNC	VGNC:55740
Others	FCRL2	NCBI

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