2. Gene
  3. FCRL2 - Fc receptor like 2 Gene

FCRL2 - Fc receptor like 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as FCRH2; IFGP4; IRTA4; SPAP1; CD307b; SPAP1A; SPAP1B; SPAP1C

Gene ID: 79368 | Gene type: protein coding

About FCRL2

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:157,745,733-157,777,132 (from NCBI)

This gene has 5 transcripts (splice variants), 42 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 14.2), spleen (RPKM 13.1) and 7 other tissues.

Summary

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]

FCRL2 Products(2)

mRNA Protein Name
NM_001159488.2 NP_001152960.1 Fc receptor-like protein 2 isoform 2 precursor
NM_030764.4 NP_110391.2 Fc receptor-like protein 2 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
11162587 GOA
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
11162587 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
16849395 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCRL2 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (23 - 102)

Ig_3

Ig_3: Immunoglobulin domain (108 - 180)

Ig_2

Ig_2: Immunoglobulin domain (208 - 292)

Ig_3

Ig_3: Immunoglobulin domain (299 - 372)

  • 0
  • 100
  • 200
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  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

Fc receptor-like protein 2

IFGP family protein 4

Recombinant FCRL2 Proteins

Cat. No. Product Name Accession Purity
HY-P76924 FCRL2 Protein, Human (HEK293, His) Q96LA5-1/NP_110391.2 (L20-D395) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04843 FCRL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FCRL2 VGNC VGNC:107873
Mus musculus FCRL2 MGD MGI:1933397
Macaca mulatta FCRL2 VGNC VGNC:72509
Rattus norvegicus FCRL2 RGD RGD:1306885
Canis familiaris FCRL2 VGNC VGNC:55740
Others FCRL2 NCBI